Table 1.

Conditional IOPcc SNP Results and Replication

					UK Biobank					EPIC-Norfolk
SNP	Pos	Locus	A1	Info	Freq	Beta	SE	P Value	N	Info	Freq	Beta	SE	P Value
rs2107482	3282064	MXRA5	G	0.986	0.316	−0.088	0.013	7.1 × 10−11	6243	0.962	0.323	−0.15	0.063	0.015
rs66819623	13954397	GPM6B	C	0.975	0.572	−0.073	0.013	6.9 × 10−10	6092	0.956	0.579	−0.13	0.061	0.026
rs12558081	43939978	NDP/EFHC2	A	0.994	0.697	−0.087	0.013	4.9 × 10−11	6323	0.966	0.610	−0.15	0.064	0.023

‘SNP’ is the variant rsid, ‘Pos’ is the base pair position (Human genome build 37), ‘Locus’ is the nearest gene/s to the SNP, ‘A1’ is the reference allele, ‘Info’ is a imputation quality score (scale 0-1), ‘Freq’ is the A1 allele frequency in each cohort for this analysis, ‘Beta’ and ‘SE’ are the linear regression coefficients and respective standard errors for the A1 allele in the respective cohort, ‘P’ is the respective association P value in each cohort, ‘N’ is the sample size for the respective allele in the EPIC-Norfolk cohort.