Table 6.
Analysis of VEGFR1 gene polymorphisms in SLE by clinical, laboratory features.
| Clinical features | rs9943922 | rs7324510 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype frequency, n (%) | P value | Allele frequency, n (%) | P value | Genotype frequency, n (%) | P value | Allele frequency, n (%) | P value | |||||||
| TT | TC | CC | T | C | CC | CA | AA | C | A | |||||
| Lupus headache | ||||||||||||||
| Positive | 2 (12.50) | 6 (37.50) | 8 (50.00) | 0.099 | 11 (34.38) | 21 (65.62) | 0.087 | 4 (25.00) | 6 (37.50) | 6 (37.50) | 0.039 | 12 (37.50) | 20 (62.50) | 0.098 |
| Negative | 60 (25.21) | 119 (50.00) | 59 (24.79) | 238 (50.00) | 238 (50.00) | 13 (5.46) | 88 (36.98) | 137 (57.56) | 116 (24.37) | 360 (75.63) | ||||
| Hypocomplementemia | ||||||||||||||
| Positive | 31 (23.66) | 65 (49.62) | 35 (27.18) | 0.960 | 128 (48.86) | 134 (51.14) | 0.940 | 5 (3.82) | 46 (38.12) | 80 (61.06) | 0.095 | 56 (21.37) | 206 (78.63) | 0.041 |
| Negative | 31 (25.20) | 60 (48.78) | 32 (26.02) | 121 (49.19) | 125 (50.81) | 12 (9.76) | 48 (39.02) | 63 (51.22) | 72 (29.27) | 174 (70.73) | ||||
| Cylindruria | ||||||||||||||
| Positive | 3 (25.00) | 2 (16.67) | 7 (58.33) | 0.026 | 7 (21.17) | 17 (70.83) | 0.046 | 1 (8.33) | 3 (25.00) | 8 (66.67) | 0.676 | 5 (20.83) | 19 (79.17) | 0.614 |
| Negative | 59 (24.38) | 123 (50.83) | 60 (24.79) | 242 (50.00) | 242 (50.00) | 16 (6.61) | 91 (37.60) | 135 (55.79) | 123 (25.41) | 361 (74.57) | ||||
| Pyuria | ||||||||||||||
| Positive | 2 (9.09) | 13 (59.09) | 7 (31.82) | 0.216 | 17 (0.386) | 27 (61.36) | 0.150 | 1 (4.54) | 7 (31.82) | 14 (63.64) | 0.744 | 9 (20.45) | 35 (79.55) | 0.448 |
| Negative | 60 (25.86) | 112 (48.28) | 60 (25.86) | 232 (50.00) | 232 (50.00) | 16 (6.90) | 87 (37.50) | 129 (55.60) | 119 (25.65) | 345 (74.35) | ||||
| Clinical features | rs9582036 | rs9554320 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype frequency, n (%) | P value | Allele frequency, n (%) | P value | Genotype frequency, n (%) | P value | Allele frequency, n (%) | P value | |||||||
| CC | CA | AA | C | A | CC | CA | AA | C | A | |||||
| Lupus headache | ||||||||||||||
| Positive | 1 (6.25) | 4 (25.00) | 11 (68.75) | 0.840 | 6 (18.75) | 26 (81.25) | 0.761 | 8 (50.00) | 7 (43.75) | 1 (6.25) | 0.896 | 23 (71.88) | 9 (28.13) | 0.653 |
| Negative | 12 (5.04) | 76 (31.93) | 150 (63.03) | 100 (21.01) | 376 (78.99) | 133 (55.88) | 93 (39.08) | 12 (5.04) | 359 (75.42) | 117 (24.58) | ||||
| Hypocomplementemia | ||||||||||||||
| Positive | 4 (3.05) | 44 (33.59) | 83 (63.36) | 0.269 | 53 (20.23) | 209 (79.77) | 0.715 | 71 (54.20) | 54 (41.22) | 6 (4.58) | 0.790 | 196 (74.81) | 66 (25.19) | 0.835 |
| Negative | 9 (7.32) | 36 (29.27) | 78 (63.41) | 53 (21.54) | 193 (78.46) | 70 (56.91) | 46 (37.40) | 7 (5.69) | 186 (75.61) | 60 (24.39) | ||||
| Cylindruria | ||||||||||||||
| Positive | 0 (0.00) | 6 (50.00) | 6 (50.00) | 0.306 | 7 (29.17) | 17 (70.83) | 0.305 | 6 (50.00) | 6 (50.00) | 0 (0.00) | 0.584 | 16 (66.67) | 8 (33.33) | 0.322 |
| Negative | 13 (5.37) | 74 (30.58) | 155 (64.05) | 99 (20.45) | 385 (79.55) | 135 (55.79) | 94 (38.84) | 13 (5.37) | 366 (75.62) | 118 (24.38) | ||||
| Pyuria | ||||||||||||||
| Positive | 4 (18.18) | 11 (50.00) | 7 (31.82) | 0.003 | 18 (40.91) | 26 (59.09) | 0.001 | 5 (22.73) | 13 (59.09) | 4 (18.18) | 0.001 | 24 (54.54) | 20 (45.45) | 0.150 |
| Negative | 9 (3.88) | 69 (29.74) | 154 (66.38) | 88 (18.97) | 376 (81.03) | 136 (58.62) | 87 (37.50) | 9 (3.88) | 358 (77.16) | 106 (22.84) | ||||
SLE systemic lupus erythematosus.