Table 1.
Neurotransmitter deficiency theorem.
| Reference | Topic | Comment |
|---|---|---|
| [27] | Ethanol-induced sleep -time with narcotic antagonism | The first experiment showing Naloxone blocking ethanol action |
| [28] | D-Phenylalanine an inhibitor of enkephalinase in the brain of genetically prone rodents | Enhanced brain endorphins with reduced ethanol intake |
| [29] | Synergistic brain effects of dopamine and ethanol | Dopamine potentiated the soporific action of ethanol |
| [30] | Synergistic brain effects of serotonin and ethanol | Serotonin potentiated the soporific action of ethanol |
| [31] | Enkephalins and drinking behavior | Low enkephalin genetically high drinking |
| [32] | Enkephalinase inhibition of alcohol intake | Inhibition of enkephalinase and precursor amino –acids results in an increase in brain enkephalins and a decrease in alcohol intake |
| [33] | Naloxone blockade of ethanol dependence | Demonstrates common mechanism between alcohol and opiates |
| [34] | Chronic alcohol intake blocks the neuronal synthesis of enkephalins | The first study to show that long-term drinking alcohol disrupts endogenous opioid peptides |
| [35] | Morphine induced attenuation of ethanol withdrawal symptoms | Further support for a common mechanism between alcohol and opiates |
| [36] | Ethanol preference as a function of genotypic levels of whole brain enkephalin in mice was studied | Enkephalin levels in genetically bred mice differ. |
| [37] | Methylated enkephalin reduces alcohol intake in genetically bred alcohol loving mice | Enkephlamide I.C. Brain injections reduced alcohol intake in C57BLK/6 J mice |
| [38] | Association of the dopamine D2 receptor A1 allele with severe alcoholism | The first association of the dopamine D2 receptor A1 allele with severe alcoholism start of Psychiatric Genetics |
| [39] | Binding studies of DRD2 receptor polymorphisms in non-alcoholics | 30–40% reduction of the number of D2 receptors s a function of the D2 polymorphism Taq A1 allele. |
| [40] | The dopamine receptor gene (DRD2) as a determinant of Reward Deficiency Syndrome (RDS) | Coined RDS now featured in SAGE Encyclopedia for Clinical & Abnormal Psychology |