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. 2020 Sep 1;11:2146. doi: 10.3389/fimmu.2020.02146

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Copyright © 2020 Rabelo, de Souza, Salomão, Machado, Pereira, Portari, Basílio-de-Oliveira, dos Santos, Neves, Morgade, Provance, Higa, Tanuri, de Carvalho and Paes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detection and quantification of collagen, MMP-2 and MMP-9 collagenases expression. (A) Collagen detection by Picro Sirius Red staining in placental tissues. (B) The percent collagen area was quantified in all cases that showed a decrease in the expression of collagen in infected placentae. (C–E) Detection of MMP-2 and MMP-9 in decidual cells and cells located within the chorionic villi in both control and ZIKV infected placentae. (D–F) Quantification of the number of cells expressing MMP-2 and MMP-9 showed an increased expression in ZIKV infected placental tissues. Data are represented as mean ± SDM. Asterisks indicate differences that are statistically significant between groups (**p < 0.01) or (***p < 0.001).