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. 2020 Sep 1;11:987. doi: 10.3389/fgene.2020.00987

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Copyright © 2020 Zhang, Shan, Chen, Sun, Liu, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CircDENND2A is up-regulated in NSCLC. (A) GEPIA database indicated DENND2A was up-regulated in NSCLC samples compared with normal tissues. (B–D) Kaplan–Meier analysis demonstrated that higher expression levels of DENND2A correlated to longer survival time in patients with NSCLC, LUAD, and LUSC by using Kaplan–Meier plotter database. (E,F) The high expression levels of DENND2A (E) and circDENND2A (F) in 20 paired NSCLC tissues by qRT-PCR (**P < 0.01). NSCLC, non-small cell lung cancer; GEPIA, Gene Expression Profiling Interactive Analysis; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma.