TABLE 3.

Correlations between ACE2 and gene markers of immune cells in OV and TGCT.

Gene type	Gene marker	OV				TGCT
		None		Purity		None		Purity
		Cor	P	Cor	P	Cor	P	Cor	P
B cell	CD19	0.043	0.457	0.031	0.624	–0.259	*	–0.214	*
	CD20	0.035	0.549	0.021	0.747	–0.167	0.042	–0.082	0.326
	CD38	0.322	***	0.348	***	–0.375	***	–0.353	***
CD8 + T cell	CD8A	0.067	0.248	0.069	0.277	–0.173	0.034	–0.095	0.252
	CD8B	–0.021	0.711	–0.049	0.443	–0.040	0.627	0.060	0.470
Tfh	CXCR5	0.158	*	0.140	0.027	–0.116	0.157	–0.019	0.824
	ICOS	0.183	*	0.194	*	–0.132	0.108	–0.033	0.692
	BCL6	0.070	0.225	0.105	0.099	0.359	***	0.363	***
Th1	IL12RB2	0.130	0.024	0.113	0.076	–0.180	0.028	–0.121	0.143
	IL27RA	0.029	0.617	0.028	0.657	0.148	0.072	0.195	0.018
	T-bet	0.142	0.013	0.161	0.011	–0.271	**	–0.227	*
Th2	CCR3	0.240	***	0.287	***	0.178	0.030	0.213	*
	STAT6	0.206	**	0.193	*	0.520	***	0.511	***
	GATA3	0.032	0.582	0.032	0.610	0.359	***	0.350	***
Th9	TGFBR2	0.045	0.434	0.041	0.520	0.409	***	0.403	***
	IRF4	0.061	0.290	0.046	0.469	–0.232	*	–0.174	0.035
	PU.1	0.061	0.292	0.074	0.246	–0.126	0.125	–0.039	0.639
Th17	IL21R	0.032	0.574	0.016	0.803	–0.197	0.016	–0.119	0.151
	IL23R	0.140	0.015	0.160	0.011	–0.124	0.129	–0.091	0.275
	RORC	0.111	0.054	0.096	0.132	0.297	**	0.337	***
	STAT3	0.096	0.094	0.113	0.076	0.380	***	0.380	***
Th22	CCR10	–0.158	*	–0.107	0.092	0.448	***	0.433	***
AHR		0.184	0.105	0.068	0.109	0.086	0.318	*⁣*⁣*	0.328
Treg	FOXP3	0.128	0.026	0.145	0.022	–0.146	0.074	–0.058	0.483
	CCR8	0.101	0.079	0.081	0.205	–0.056	0.492	–0.019	0.815
	CD25	0.009	0.872	0.044	0.486	–0.152	0.064	–0.066	0.428
T cell exhaustion	PD-1	0.112	0.052	0.146	0.021	–0.282	**	–0.243	*
	TIM-3	0.116	0.044	0.143	0.024	–0.101	0.221	0.000	0.996
	LAG3	0.258	***	0.311	***	–0.300	**	–0.267	*
	CTLA4	0.152	*	0.195	*	–0.250	*	–0.193	0.019
Macrophage	CD68	0.098	0.088	0.119	0.060	–0.023	0.780	0.073	0.378
	CD11b	0.067	0.244	0.059	0.357	–0.031	0.702	0.043	0.609
M1	NOS2	0.080	0.165	0.127	0.046	0.385	***	0.365	***
	CD86	0.141	0.014	0.174	*	–0.133	0.104	–0.041	0.625
	CD80	0.216	**	0.255	***	–0.181	0.027	–0.111	0.180
	ROS	0.070	0.222	0.094	0.141	0.482	***	0.452	***
M2	ARG1	–0.003	0.957	–0.023	0.716	0.211	*	0.169	0.041
	CD163	0.094	0.104	0.116	0.068	0.281	**	0.322	***
TAM	HLA-G	0.229	***	0.221	**	0.213	*	0.232	*
Monocyte	CD14	0.023	0.690	0.040	0.529	0.150	0.066	0.220	*
	CD16B	0.147	0.011	0.155	0.014	0.252	*	0.248	*
NK	XCL1	–0.054	0.345	–0.043	0.496	–0.039	0.639	0.017	0.842
	CD56	–0.108	0.059	–0.071	0.264	0.512	***	0.499	***
	KIR3DL1	0.138	0.016	0.166	*	–0.157	0.054	–0.077	0.355
	CD7	0.120	0.036	0.145	0.022	–0.174	0.034	–0.099	0.231
Neutrophil	CD15	0.248	***	0.250	***	–0.127	0.123	–0.068	0.411
DC	CD1C	–0.078	0.178	–0.131	0.039	0.276	**	0.330	***
	CD141	0.009	0.882	0.018	0.776	0.639	***	0.627	***
	CLEC9A	0.092	0.111	0.126	0.048	–0.355	***	–0.318	***
Breg	CD1d	0.051	0.372	0.014	0.823	0.016	0.843	0.077	0.355
	CD5	0.107	0.064	0.108	0.090	–0.132	0.107	–0.035	0.671

OV, ovarian serous cystadenocarcinoma; TGCTs, testicular germ cell tumors; Tfh, follicular helper T cell; Th, T helper cell; Treg, regulatory T cell; TAM, tumor-associated- macrophage; NK, natural killer cell; DC, dendritic cell; Breg, regulatory B cell; Purity, correlation adjusted for tumor purity; Cor, R-value of Spearman’s correlation. *P < 0.01; **P < 0.001; ***P < 0.0001.