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. 2020 Sep 14;10:15029. doi: 10.1038/s41598-020-71623-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Simulations of brain spectra for 7 T and ASE excitation (TE1/TE2 = 50/28 ms) under increasing linewidths. (A) Simulated (black) and fitted (red) spectrum for LW = 3 Hz (0.01 ppm); (B) Simulated (black) and fitted (red) spectrum for LW = 30 Hz (0.1 ppm); (C) Overlay of simulated brain spectra for increasing linewidth; (D) Overlay of 2HG spectra fitted by LCModel in the simulated brain spectra for increasing linewidth; (E) Accuracy of 2HG fitting for increasing linewidth (1 ± 0.1 fit/true is considered acceptable interval; true value as dashed horizontal red line, vertical red line the maximum acceptable linewidth); (F) Precision of 2HG fitting for increasing linewidth (CRLB < 20% is considered acceptable precision; 20% marked by dashed horizontal red line, vertical red line the maximum acceptable linewidth). The vertical dashed line at 2.25 ppm in (A–D) indicates the position of the negative 2HG peak for TE = 78 ms.