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. 2020 Sep 14;10:15029. doi: 10.1038/s41598-020-71623-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of MRSI in the third healthy volunteer under five shimming conditions 2SH_box, 2SH_brain, 2SH_box + AC/DC_brain, 2SH_brain + AC/DC_brain, and (2SH_brain + AC/DC_brain)_joint. An inferior axial slice is shown from the stack of 3D MRSI data as indicated by the blue dashed line in the coronal and sagital views at the top. The metabolic maps of total NAA (tNAA), total Choline (tCho), total Creatine (tCr), linewidth (FWHM), signal-to-noise ratio (SNR), and Cramer-Rao lower bounds (CRLB of tCr) are shown for all shimming methods. Examples of spectra from frontal (cyan box), left lateral (green box), right lateral (pink box), and occipital (black box) voxels are shown overlaid for all shimming conditions. The values under the maps indicate the mean and standard deviation calculated over the whole-brain slab. MEMPRAGE anatomical image is shown at the top, with the limits of the MRSI slab shown on the sagital and coronal slices by the red dashed lines.