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. 2020 Sep 14;10:15029. doi: 10.1038/s41598-020-71623-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Integrated RF-receive/B₀-shim (AC/DC) array coil (left) and digitally programmable shim supply boards (right). (B) 3D MRSI pulse sequence diagram with real-time motion correction and dynamic AC/DC shim update. Echo time TE = 78 ms (TE1/TE2 = 50/28 ms), inversion recovery delay TI = 270 ms, TR = 1,800 ms, FOV = 220 × 220 × 80 mm³, matrix 44 × 44 × 8, nominal voxel 5 × 5 × 10 mm³, spectral window 2,700 Hz, acquisition time = 11:38 min:s. 2SH = 2nd-order spherical harmonics; AC/DC = alternating/direct current; AHP = adiabatic half passage; GOIA = gradient offset independent adiabatic; EPI = echo planar imaging; HGSB = hypergeometric single band; WET = water suppression enhanced through T₁ effects. Shown at the bottom: B₀ fieldmaps for 2SH and 2SH + ACDC shimming; the spiral out-in k-space trajectory; the slice profile of GOIA pulses simulated for ± 1 ppm offset; the inversion profile of the HGSB pulse with transition band centered (red dashed line) at 1.6 ppm.