Figure 4.

Acetaminophen Prevents Severe Hypoxia and Rescues Postictal Amnesia. (a) Experimental paradigm—Object-Context Mismatch. (b) Oxygen recordings just prior to the memory task that demonstrate experimental separation of seizure from the resulting hypoxic event by acetaminophen pre-treatment. (c) Investigation ratio of the novel object to the familiar object for the paired context. Acetaminophen prevented the seizure-induced memory impairment observed in vehicle-treated rats and performed no differently from sham controls (ANOVA F(2,40) = 8.82, follow-up Tukey’s test displayed, **p < 0.01, ***p < 0.0001).