Table 3. Biologic agents in the treatment of severe asthma.

Biologic class	Biologic agent (administration schedule)	Approved for use	Approved for self-administration
Anti-IgE	Omalizumab (every 2–4 weeks s.c.)	From age 6	Yes
Anti-IL-5	Mepolizumab (every 4 weeks s.c.)	From age 6	Yes
Anti-IL-5	Reslizumab (every 4 weeks i.v.)	From age 18	No
Anti-IL-5-(R)	Benralizumab (every 8 weeks s.c.)	From age 18	Yes
Anti-IL-4/13	Dupilumab (every 2 weeks s.c.)	From age 12	Yes

The table shows the currently approved biologic agents, which may be classified in three different classes. The patient age from which they are approved for use is also given. Almost all these biologics are approved for self-administration. s.c., subcutaneously