Table 1.

Examples of Novel Splice Variants Expressed in HCC and Associated Cellular Pathways

Gene	Protein	Splice variant isoform	Major associated pathway	Literature source
BIN1	Myc box-dependent-interacting protein-1	Long variant BIN1L	Regulation of membrane signaling and Myc	Malakar et al, Cancer Res 2017
CCDC50	Coiled-coil domain-containing protein 50	Short variant CCDC50S	Ubiquitin-proteasome, cytoskeleton	Wang et al, Hepatology 2019
INSR	Insulin receptor	Short variant IR-A	Insulin signaling	Chettouh et al, Cancer Res 2013
KHK	Ketohexokinase	Variant KHK-A	Fructose metabolism	Li et al, Nat Cell Biol 2016
NF2	Merlin	Short variant Δ2-4Merlin	Hippo signaling/cell growth and proliferation	Luo et al, Nat Commun 2015
NT5E	Ecto-5'-nucleotidase (CD73)	Short variant CD73S	Extracellular adenosine production	Snider et al, Mol Biol Cell 2014
NUMB	Protein numb homolog	Long variant PRR (L)	Tissue morphogenesis	Lu et al, Hepatology 2015
RCAN1	Calcipressin-1	Variant isoform 4	Regulation of transcription	Jin et al, Gastroenterology 2017
TLL1	Tolloid-like protein 1	TLL1 short variant	Extracellular matrix and cell differentiation	Matsuura et al, Gastroenterology 2017