Figure 8.

ROS, RNS, and autophagy pathways cooperate for optimal IL23-induced bacterial clearance. MDMs were transfected with scrambled or the indicated siRNAs, alone or in combination (comb), and then treated with (A) IL23 or (B) IL12 for 48 hours. Intracellular clearance of E faecalis, AIEC, or S Typhimurium. Mean CFU + SEM (n = 4). ∗∗P < .01, ∗∗∗P < .001, and ^†P < 1 × 10^-4 as indicated. Significance between combined siRNA and p47phox siRNA was as follows: ^♯P < .01 and ^‡P < .001. Scr, scrambled; Tx, treatment.