Table 8.

Fundamental elements in the design of animal study for intraperitoneal hernia mesh [93].

Fundamental elements	Relevant content in the guidance
Animal species	Large mature animals (such as minipigs and beagles)
Selection of control	The most similar marketed intraperitoneal mesh in terms of material and structural design in China.
Selection of evaluation criteria	Adhesion strength, adhesion area, acceptable rate of adhesion, condition of newly-grown peritoneum, adverse reactions, and histological reactions.
Selection of observation time	For non-absorbable adhesion reducing materials, at least observe for 28 days after implantation. For absorbable adhesion reducing materials, the observation period should be determined according to the expected time of complete degradation of the product.