Table I.
Laboratory values
| CBC | Normal pediatric | Patient 1 |
Normal adults | Patient 2 |
Patient 3 |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Admit | Peak | Discharge | Admit | Peak | Discharge | Admit | Peak | Discharge | |||
| WBC | 4.5-11.4 × 103/μL | 3.2 | 14.3 | 14.3∗ | 4.5-11.0 × 103/μL | 4.2 | 9.2 | 4.4 | 6.4 | 6.4 | 5.3 |
| HGB | 10.6-14.4 g/dL | 6.6 | 10.2 | 10.0∗ | 13.9-16.3 g/dL | 10.8 | 10.9 | 10.8 | 12.6 | 12.6 | 11.3 |
| PLTS | 150-450 × 103/μL | 134 | 193 | 175∗ | 150-450 × 103/μL | 260 | 391 | 333 | 248 | 248 | 187 |
| Lymph % | 12.2%-48.4% | 31.7 | 34 | 23.0∗ | 12.2%-48.4% | 28.8 | 61.4 | 54.6 | 17.0 | 29.3 | 24.7 |
| Inflammatory markers | Normal pediatric | Admit | Peak | Discharge | Normal adults | Admit | Peak | Discharge | Admit | Peak | Discharge |
|---|---|---|---|---|---|---|---|---|---|---|---|
| CRP | 0.0-5.0 mg/L | — | 22.4 | 6.7† | 0.0-5.0 mg/L | 64 | 64 | 18.4 | 15.2 | 16.4 | 13.4 |
| ESR | 0-10 mm/h | — | 35 | — | 0-15 mm/h | 89 | 89 | — | — | — | — |
| LDH | 150-260 U/L | — | 530 | — | 100-220 U/L | 214 | 289‡ | 210 | 183 | 183 | — |
| Ferritin | 20-200 ng/mL | — | 642 | 642† | 30-400 ng/mL | 123 | 185 | 166 | 967 | 967 | 775 |
| IL-1β§ | 0-5.0 pg/mL | — | <0.3 | — | 0-5.0 pg/mL | 8.6 | 8.6 | <0.3 | <0.3 | 0.5 | 0.5 |
| IL-6§ | 0-5.0 pg/mL | — | 11.1 | — | 0-5.0 pg/mL | 20.5 | 20.5 | 3.8 | 14.1 | 15.1 | 15.1 |
| IL-8§ | 0-5.0 pg/mL | — | 12.7 | — | 0-5.0 pg/mL | 27.3 | 27.3 | 21.4 | 6.7 | 8.5 | 8.5 |
| TNF-α§ | 0-22.0 pg/mL | — | 19.8 | — | 0-22.0 pg/mL | 18.0 | 18.1 | 18.1 | 15.3 | 15.3 | 13.7 |
| Coagulation studies | Normal pediatric | Admit | Peak | Discharge | Normal adults | Admit | Peak | Discharge | Admit | Peak | Discharge |
|---|---|---|---|---|---|---|---|---|---|---|---|
| INR | 0.8-1.2 | — | 1.3 | — | 0.8-1.2 | 1.1 | 1.1 | 1.0 | 0.9 | 1.0 | 1.0 |
| D-Dimer | 0.00-0.50 μg/mL | — | 1.23 | 0.30∗ | 0.00-0.50 μg/mL | 0.67 | 1.04 | 0.28 | 0.45 | 0.45 | — |
| Immune regulation | Normal pediatric | Admit | Peak | Discharge | Normal adults | Admit | Peak | Discharge | Admit | Peak | Discharge |
|---|---|---|---|---|---|---|---|---|---|---|---|
| IgG quantitative | 698-1560 mg/dL | 560 | — | — | 700-1600 mg/dL | 821‖ | — | — | 1057 | — | — |
| Absolute B- cell count | 432-3345/mm3 | 13¶ | — | 25-335/mm3 | 1¶ | — | — | 3¶ | — | — |
ESR, Erythrocyte sedimentation rate; HGB, hemoglobin; INR, international normalized ratio; LDH, lactate dehydrogenase; Lymph%, lymphocyte percentage; PLTS, platelets; WBC, white blood cell count.
Bolded numbers are abnormal lab values. Pediatric ranges are given for patient 1 and adult ranges for patients 2 and 3.
These values are from 1 d before discharge.
These values are from 3 d before discharge.
A value of more than 10 times this is the recorded peak; however, it does fit with the remainder of the patient's clinical data.
For patients with COVID-19 aged 10-40 y at our institution, the first to third quartile ranges are 0.1-0.7 pg/mL for IL-1β, 9.9-70.8 pg/mL for IL-6, 13.3-44.3 pg/mL for IL-8, and 11.6-28.0 pg/mL for TNF-α.9
Before IVIG; later increased to 1021 on readmission.
At diagnosis.