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. 2020 Sep 14;11:4608. doi: 10.1038/s41467-020-18462-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a A set of 56 crude extracts derived from the Wright Actinomycete Collection (WAC) were generated and tested for growth inhibition against model prokaryote (E. coli, B. subtilis), yeast (S. cerevisiae, C. albicans) and insect (D. melanogaster) model organisms. Visualized is each extract’s inhibitory activity against corresponding model organisms where values of microbial growth are relative to the DMSO control. Asterisks (*) indicate extracts that had larvicidal activity whereby no larvae developed into adult flies. b Shown is the activity of an extract from WAC-288 which inhibited the development of D. melanogaster larvae into adult flies. c The molecule with larvicidal activity was purified from WAC-288 and its identity was confirmed via tandem MS/MS fragmentation analysis. The parent ion and the masses of corresponding fragments were identified (Supplementary Fig. 2). d Structure of the antibiotic cosmomycin D. e Biosynthetic gene cluster identified from the sequenced genome of WAC-288 corresponding to cosmomycin D production.