Table I.
Details of reported cases of malignant mesothelioma metastastic to the oral region.
| Case no. | First author | Sex | Age at diagnosis (years) | Oral site | Histopathology of metastasis | Immunopathology (+) | Immunopathology (-) | (Refs.) |
|---|---|---|---|---|---|---|---|---|
| 1 | Kerpel | M | 73 | 2x2-cm submucosal mass of ventral tongue | Epithelioid with glandular areas | Cytokeratin | Vimentin, CEA, B72.3 | (30) |
| 2 | Kerpel | M | 45 | Mass on lower gingiva with assosiated bone loss of the mandible | Epithelioid with glandular areas | Cytokeratin, focally vimentin | Leu-M1, CEA, B72.3 | (30) |
| 3 | Sproat | M | 48 | Mandibular alveolus | Sarcomatoid | Vimentin, focally cytokeratin (CAM5.2) | CEA, EMA | (31) |
| 4 | Piattelli | M | 52 | Lesion on lateral tongue | Epithelioid | Vimentin, cytokeratin | CEA, B72.3, Leu-M1 | (32) |
| 5 | Garcia-Reija | M | 63 | Lower gingiva | Epithelioid with glandular areas | Vimentin | Not stated | (33) |
| 6 | Cassarino | M | 64 | 0.8x0.7-cm ulcerated nodule of the upper lip | Epithelioid with glandular areas | Cytokeratins (AE1/3,CK19), HBME-1 | CEA, BER-EP4, B72.3, Leu-M1 | (34) |
| 7 | Zanconati | M | 71 | Ulcerated mass on dorsolateral tongue | Epithelioid | Keratins, EMA, vimentin, thrombomodulin, calretinin | Not stated | (35) |
| 8 | Soyuer | F | 50 | 0.8-cm mass in the buccal mucosa | Not stated | Cytokeratin cocktail, CEA, Leu-M1, B72.3, EMA, calretinin, vimentin | Not stated | (36) |
| 9 | Terakado | M | 53 | Periapical radiolucency associated with mandibular third molar | Sarcomatoid | Vimentin, cytokeratin-AE1/3 | CD34, CK10, BER-EP4 | (37) |
| 10 | Tho | M | 70 | 2x1-cm lession on lateral tongue | Biphasic | Calretinin, mesothelin, CK5 | CEA, TTF-1, thrombomodulin | (38) |
| 11 | Higginson | M | 69 | 2.2x0.9-cm submucosal mass in floor of mouth with involvement of the tongue | Epithelioid | Calretinin, CK5/6, AE1/3, CD15 | BER-EP4, mucicarmine | (39) |
| 12 | Hashitani | F | 59 | 0.5x0.5-cm nodule on dorsal tongue | Epithelioid with glandular areas | CK5/6, AE1/3, EMA, calretinin, HBME-1, mesothelin, TTF-1 | Not stated | (40) |
| 13 | Kirke | M | 71 | 3-cm submucosal mass in floor of mouth with involvement of the tongue | Poorly differentiated with squamoid cells | MNF116 keratin, EMA, CK5, calretinin | Not stated | (41) |
| 14 | Murray | F | 46 | 1x0.5-cm nodule on dorsal tongue | Epithelioid with glandular areas | CK7, CK19, AE1/3, CA125, EMA | CD31, CD34, Bcl2, GCDFP15, alpha actin, CK20, S100, CDX2, CEA, ER, TTF-1 | (42) |
| 15 | Sinon | M | 65 | 0.8-cm submucosal mass in buccal mucosa | Epithelioid with pseudoglandular areas | CK5/6, CK7, CK19, CAM5.2, EMA, calretinin, WT1 | Not stated | (43) |
| 16 | Billè | F | 68 | Mandibular alveolus | Sarcomatoid | WT1, calretinin | Claudin-4, BER-EP-4 | (44) |
| 17 | Arslan | M | 59 | Retromolar trigone area | Epithelioid | Calretinin | Not stated | (45) |
| 18 | Ohnishi | M | 62 | 3x2.5-cm mass in maxillary gingiva | Epithelioid | Vimentin, focally cytokeratin | CEA, EMA | (46) |
| 19 | Moser | M | 75 | 1.5-cm mass in lower right molar gingiva | Epithelioid | Calretinin, CK5/6 | BER-EP4 | (47) |
| 20 | Sawaki | M | 75 | 3.8x2-cm mass in upper gingiva | Epithelioid | Vimentin, focally keratin AE1/3 | CEA, LCA, CD3, CD20, CD79, S-100, HMB-45 | (48) |
| 21 | Vazquez | M | 66 | 3-cm mass in the anterior 2/3 of the tongue | Epithelioid | Not stated | Not stated | (49) |
| 22 | Arslan | M | 59 | Retromolar trigone area | Epithelioid | Calretinin | Not stated | (45) |
| 23 | Tanaka | M | 66 | 0.5-cm mass in the left buccal gingiva of the maxilla | Epithelioid | Calretinin, thrombomodulin, CAM5.2 | MOC31, BER-EP4, TTF-1 | (50) |
CK, cytokeratin; EMA, epithelial membrane antigen; CEA, carcinoembryonic antigen; LCA, leukocyte common antigen; TTF-1, thyroid transcription factor 1; HMB-45, human melanoma black 45; WT1, Wilms' tumor 1; HBME-1, Hector Battifora mesothelial epitope-1; ER, estrogen receptor; BER-EP4, anti-human epithelial antigen; GCDFP15, gross cystic disease fluid protein-15.