Table 1:
Demographics of the cohort stratified by presence of Pulmonary Dysfunction at Discharge (PDAD)
| Variable | Whole cohort (n = 255) |
No PDAD (n = 168) |
PDAD (n = 87) |
p value |
|---|---|---|---|---|
| Demographics | ||||
| Age (months) (median) (IQR) | 2 (1, 4) | 15 (1, 3) | 2.5 (1.5, 9) | <0.001 |
| Female/male (%/%) | 100/155 (39/61) | 65/103 (39/61) | 35/52 (40/60) | 0.892 |
| Non-white race (%) | 52 (20) | 33 (20) | 19 (22) | 0.744 |
| Hispanic ethnicity (%) | 50 (20) | 30 (18) | 20 (23) | 0.609 |
| Admission diagnosis (%) | ||||
| RSV bronchiolitis | 132 (52) | 93 (55) | 39 (45) | 0.079 |
| Other bronchiolitis | 57 (22) | 40 (24) | 17 (20) | |
| Other pneumonia | 31 (12) | 14 (8) | 17 (20) | |
| Other respiratory failure | 29 (11) | 17 (10) | 12 (14) | |
| Non-pulmonary | 6 (2) | 4 (2) | 2 (2) | |
| PRISM III score | 4 (2, 6) | 4 (2, 6) | 4 (3, 6) | 0.93 |
| Oxygenationa | ||||
| Worst OI (n = 184) | 6.2 (3.2, 10.8) | 6.6 (3.5, 10.4) | 9.7 (4.6, 16.2) | 0.014 |
| Highest ventilator parameters | ||||
| PIP (cmH2O)(n = 253) | 32 (28, 36) | 31 (27, 35) | 33 (29, 37) | 0.020 |
| PEEP (cmH2O)(n = 253) | 5 (5, 8) | 5 (5, 7) | 6 (5, 8) | 0.050 |
| First Three-day average ventilator parameters | ||||
| PIP (cmH2O)(n = 251) | 27.3 (23.3, 31.3) | 26.7 (22.7, 30.7) | 29 (25, 33) | 0.005 |
| PEEP (cmH2O)(n = 246) | 5 (5, 6) | 5 (5, 6) | 5 (5, 7) | 0.038 |
| Specific virus positive (%)(n 193) | ||||
| RSV | 144 (75) | 104 (79) | 40 (65) | 0.034 |
| Influenza | 7 (4) | 5 (4) | 2 (3) | 1 |
| Parainfluenza | 5 (3) | 2 (2) | 3 (5) | 0.330 |
| Adenovirus | 3 (2) | 1 (1) | 2 (3) | 0.242 |
| Bacterial culture positive (%)(n = 201) | 140 (70) | 85 (63) | 55 (82) | 0.009 |
| Duration of support | ||||
| Ventilator days | 5 (4, 9) | 5 (4, 9) | 6 (4, 11) | 0.28 |
| Oxygen days | 9 (6, 12) | 9 (6, 12) | 9 (6, 12) | 0.80 |
| PICU days | 7 (5, 12) | 7 (5, 11) | 8 (5, 15) | 0.08 |
| Hospital days | 12 (8, 17) | 11 (8, 15.5) | 12.5 (8, 20) | 0.21 |
| Mortality (%) | 6 (2) | 2 (1) | 4 (5) | 0.185 |
| Pulmonary dysfunction at discharge (%) | ||||
| Mechanical ventilation | 4 (2) | - | 4 (5) | - |
| Supplemental oxygen | 16 (6) | - | 16 (18) | - |
| Oral/inhaled corticosteroids | 36 (14) | - | 36 (41) | - |
| Bronchodilator | 67 (26) | - | 67 (77) | - |
a
OSI is converted to OI