Table 1.

Optimization procedure NDPC production.

Procedure	Diameter size (nm)	PI	Crystalline properties
Wet milling	515.5	0.215	Physical mixture
Neat grinding	857.9	0.353	Co-crystal
Phase inversion globule	310.0	0.316	Physical mixture
Fast evaporation + microwaving	598.2	0.278	Co-crystal