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. 2020 Sep 14;18:124. doi: 10.1186/s12915-020-00854-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Pten over-expression in astrocyte-like glia is sufficient to extend lifespan without delaying development. a Drosophila glia comprise several distinct subsets, including the perineurial and subperineurial glia that form the blood-brain barrier, cortex glia that surround neuronal cell bodies, ensheathing glia that line the neuropil, and astrocyte-like glia whose processes infiltrate the neuropil. Panel adapted from [40]. b Survival curves show reduced lifespan for w^Dah;UAS-Pten/NP6293-GAL4;+ flies (red) compared to control w^Dah;NP6293-GAL4/+;+ (blue) and w^Dah;UAS-Pten/+;+ (black) flies. c Survival curves show reduced lifespan for w^Dah;UAS-Pten/NP2222-GAL4;+ flies (red) compared to control w^Dah;NP2222-GAL4/+;+ (blue) and w^Dah;UAS-Pten/+;+ (black) flies. d Survival curves show extended lifespan for w^Dah;UAS-Pten/+;alrm-GAL4/+ flies (red) compared to control w^Dah;+;alrm-GAL4/+ (blue) and w^Dah;UAS-Pten/+;+ (black) flies. For all lifespans, n > 140 deaths counted per group. e Egg-to-adult timing shows unaffected development timing for w^Dah;UAS-Pten/+;+ flies (black) compared to control wDah;+;+ flies (green). f Egg-to-adult timing shows delayed development timing for w^Dah;UAS-Pten/NP6293-GAL4;+ flies (red) compared to control w^Dah;NP6293-GAL4/+;+ flies (blue). g Egg-to-adult timing shows delayed development timing for w^Dah;UAS-Pten/NP2222-GAL4;+ flies (red) compared to control w^Dah;NP2222-GAL4/+;+ flies (blue). h Egg-to-adult timing shows unaffected development timing for w^Dah;UAS-Pten/+;alrm-GAL4/+ flies (red) compared to control w^Dah;+;alrm-GAL4/+ flies (blue). For all development assays, n > 70 flies counted per group. p values are from log-rank tests versus control group of that colour