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. 2020 Sep 14;39:186. doi: 10.1186/s13046-020-01697-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — High hsa_circ_0001944 expression predicted an unfavorable prognosis in BC patients. a The total differential expression of circRNAs. b Volcano plots illustrate that among significantly different expressed circRNAs, 12 were upregulated and 78 were downregulated in BC tissues relative to normal tissues. c The expression and subcellular localization of hsa_circ_0001944 in BC was analyzed by in situ hybridization in a BC tissue. d RT-qPCR detection show the differential expression of hsa_circ_0001944 in 90 paired BC tissues. Data are presented as mean ± SD; ^***P < 0.001 vs. normal group. e hsa_circ_0001944 expression among 90 patients was analyzed for overall survival. f The genomic locus of hsa_circ_0001944