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. 2020 Sep 14;39:186. doi: 10.1186/s13046-020-01697-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Downregulation of hsa_circ_0001944 suppressed BC invasion both in vitro and in vivo. a and b Cell migration was assessed in both T24 and UMUC3 cells using transwell assays. Data are presented as mean ± SD; ^***P < 0.001 vs NC. c and d Wound healing assays show the invasion ability of both T24 and UMUC3 cells. Data are presented as mean ± SD; ^***P < 0.001 vs NC. e Live imaging showing the effects of hsa_circ_0001944 on the metastasis of T24 cells 30 d after intravenous tail injection. f Immunohistochemistry showing the percentage of Ki-67-positive cells. g-i RT-qPCR detection show the expression of hsa_circ_0001944 (G), miR-548 (H) and PROK2 (I) in tumor tissues. Data are presented as mean ± SD; ^***P < 0.001 vs. NC