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. 2020 Sep 14;39:186. doi: 10.1186/s13046-020-01697-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Downregulation miR-548 or overexpression PROK2 restored the proliferation and invasiveness of BC cells after has_circ_0001944 was silenced. a-c Colony formation assays show the proliferation of both T24 and UMUC3 cells after transfection with si-hsa_circ_0001944, miR-548 inhibitor, or PROK2 overexpression vector, either singly or in combination. Data are means ± SD. ***P < 0.001 vs. NC. ^###P < 0.001 vs. si-circRNA. d-f Edu assay shows the proliferation of both T24 and UMUC3 cells after transfection with si-has_circ_0001944, miR-548 inhibitor, or PROK2 overexpression vector, either singly or in combination. Data are means ± SD. ***P < 0.001 vs. NC. ^###P < 0.001 vs. si-circRNA. g-i Transwell migration assays of both T24 and UMUC3 cells. Data are means ± SD. ***P < 0.001 vs. NC. ^###P < 0.001 vs. si-circRNA