Table 2.

Clusters showing positive correlations between posterior putamen functional connectivity and ¹¹C-PE2I BP_ND and disease severity (Bradykinesia-Rigidity sub-score), as revealed by voxel-wise multiple regression analysis for all PD patients. Longitudinal multiple regression using difference maps (Δ: follow-up – baseline) from the PD_FU group are also shown.

Seed		Covariate of Interest	Cluster		Peak T	MNI Coordinates			Brain Region
			p Value*	k		x	y	z
Posterior putamen	Baseline Analysis(n = 30)	11C-PE2I BPND	0.027	22	4.65	0	−18	−12	Midbrain
	Follow-up Analysis(n = 15)	Δ 11C-PE2I BPND	0.007	580	5.37	−4	−26	−8	Midbrain, extending into thalamus
			0.001	845	4.66	10	−4	72	Supplementary motor area
			0.031	376	4.39	−36	−36	54	Postcentral gyrus, extending into precentral gyrus
		Δ Bradykinesia-Rigidity sub-score	0.032	48	6.37	24	6	−10	Posterior putamen

Threshold of p < 0.001 uncorrected at voxel-level and p < 0.05 corrected for false discovery rate at cluster-level.

Coordinates of peak voxels (x, y, z) are given in Montreal Neurologic Institute (MNI) space.

*Indicates correction for false discovery rate.