Table 5.

Only weight reduction model

Biological factors related to hyperglycemia	Threshold	Relevance
Fasting glucose	<118–133 mg/dL	0.07
A1c reduction speed	>−0.10 point HbA1c/year	0.81
Distance from target 7%	<0.7–0.9 point HbA1c	0.12

Biological factors related to insulin resistance	Threshold	Relevance
BP systolic	<115–125 mm Hg	0.03
Total cholesterol	<189 mg/dL	0.04
Triglycerides	<125 mg/dL	0.02
HDL	>47	0.02

Hystory and care	Threshold or condition	Relevance
Years of observation	>10	0.16
Interval between visits (yeras)	<0.4–0.6	0.28
BMI	>26–28	0.12

Diabetes therapy	Condition	Relevance
Agents	Absent	0.09
SGLT2i, GLP1-RA, DPP-4i, INS+SGLT2 i, INS+GLP1 RA, INS+DPP-4i	Present	0.09

The model identifies the following factors as relevant for achieving the target: AUC 0.55, accuracy 0.62, sensitivity 0.65, specificity 0.48, precision 0.82, NPV 0.29.

AUC, area under the curve; BMI, body mass index; BP, blood pressure; DPP-4i, dipeptidyl peptidase 4 inhibitor; GLP-1RA, glucagon-like peptide-1 receptor agonists; HDL, high density lipoprotein; INS, insulin; NPV, negative predictive value; SGLT2i, sodium-glucose cotransporter-2 inhibitors.