Figure 1:

Overlap of Differentially Processed Genes in ARDS Correlates with the Literature Suggesting ARDS Models are Robust. A) Consolidated list of genes reported to be associated with ARDS over the past 50 years[2] were overlapped with the significant genes from the differential expression and alternative processing analyses. Of the 89 genes reported the 11 genes were found to overlap in all three categories. B) Directionality of the change in expression of the eleven genes was then assessed. Arrows indicate whether each gene is enriched (up) or depleted (down) in each sample (HL=human lung, ML=mouse lung, HB=human blood, MB=mouse blood) for each category (Alternative Splicing, Alternative Transcription). Two arrows indicate multiple isoforms were found to be significant in different directions. C) GO terms analysis was performed on the overlapping genes resulting in twenty significantly enriched biological processes.