Table 4.
Transfusion reaction characterization.
| Number of adjudicated transfusion reactions | Percentage (%) of total adjudicated transfusion reactions (N = 70) | Percentage (%) of total transfusions in each group | P value | |
|---|---|---|---|---|
| Sex | 0·9036 | |||
| Female | 37 | 52·9 | 1·99 | |
| Male | 33 | 47·1 | 2·10 | |
| Age | 0·0757 | |||
| 0–10 years | 15 | 21·4 | 3·23 | |
| 11–18 years | 14 | 20·0 | 1·40 | |
| 19–25 years | 41 | 58·6 | 2·09 | |
| Race/Ethnicity | 0·9359 | |||
| Caucasian (non-Hispanic/Latino) | 25 | 35·7 | 2·30 | |
| Hispanic/Latino | 27 | 38·6 | 1·91 | |
| Black | 11 | 15·7 | 2·24 | |
| Asian | 3 | 4·3 | 1·47 | |
| Other/Unknown | 4 | 5·7 | 1·75 | |
| Product | 0·0318 | |||
| Platelets | 48 | 68·6 | 2·78 | |
| Red blood cells | 22 | 31·4 | 1·49 | |
| Thawed plasma | 0 | 0 | 0 | |
| Cryoprecipitate | 0 | 0 | 0 | |
| Granulocytes | 0 | 0 | 0 | |
| Underlying diagnosis | ||||
| Haematopoietic cell transplant | 23 | 32·9 | 1·96 | 0·7940 (major diagnosis categories) |
| Autologous | 9 | 12·9 | 3·53 | 0·1047 (diagnosis subtypes) |
| Immune effector cell therapy | 3 | 4·3 | 3·95 | |
| Allogeneic | 11 | 15·7 | 1·31 | |
| Matched related donor | 3 | 4·2 | 2·50 | |
| Matched unrelated donor | 3 | 4·2 | 1·10 | |
| Haploidentical | 0 | 0 | 0 | |
| Mismatched unrelated donor | 0 | 0 | 0 | |
| Umbilical cord blood | 5 | 14·2 | 1·62 | |
| Bone marrow source | 4 | 5·7 | 1·23 | |
| Peripheral blood stem cells | 2 | 2·9 | 0·97 | |
| Myeloablative | 11 | 15·7 | 1·51 | |
| Reduced toxicity conditioning | 0 | 0 | 0 | |
| Non-haematopoietic cell transplant | 47 | 67·1 | 2·08 | |
| Leukemia/lymphoma | 29 | 41·4 | 2·04 | |
| Acute lymphoblastic leukemia | 14 | 20·0 | 2·44 | |
| Acute myeloid leukemia | 15 | 21·4 | 1·89 | |
| Lymphoma | 0 | 0 | 0 | |
| Solid tumors | 16 | 22·9 | 2·46 | |
| Ewing sarcoma | 2 | 2·9 | 1·31 | |
| Osteosarcoma | 5 | 7·1 | 3·79 | |
| Rhabdomyosarcoma | 0 | 0 | 0 | |
| Brain tumors | 5 | 7·1 | 4·81 | |
| Other | 4 | 5·7 | 1·96 | |
| Benign haematologic conditions | 2 | 2·9 | 1·18 | |
| Transfusion reaction type | ||||
| Febrile non-haemolytic transfusion reaction | 43 | 61·4 | – | – |
| Premedication with acetaminophen and/or hydrocortisone | (24/43) | (55·8) | ||
| Allergic | 25 | 35·7 | – | |
| Premedication with diphenhydramine and/or hydrocortisone | (19/25) | (76·0) | ||
| Transfusion-associated circulatory overload | 2 | 2·9 | – | |
| Transfusion-associated acute lung injury | 0 | 0 | – | |
| Haemolytic transfusion reaction | 0 | 0 | – | |
| Severity | ||||
| Non-severe | 62 | 88·6 | ||
| Severe/Life-threatening | 5 | 7·1 | ||
| Death | 0 | 0 | ||
| Not determined | 3 | 4·3 |