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. 2020 Aug;9(2):83–87. doi: 10.15420/aer.2020.03

Table 2: Comparison of Left Atrial Appendage Occlusion in the UK Compared with Rest of the World.

UK RoW
Betts et al. 2017[34] (n=371) CtE registry, 2019[21] (n=525) Williams et al. 2018[33] (n=117) PROTECT AF, 2019[36] (n=463)[1] PREVAIL, 2014[35] (n=269)* Tzikas et al. 2016[37] (n=1,047)
Mean age, years (SD) 72.9 (8.3) 74.5 (8.0) 75.6 (NA) 71.7 (8.8) 74.0 (7.4) 75.0 (8.0)
Male (%) 88.9 68.7 66.7 70.4 67.7 62.0
Study population Any indication† AC contraindicated AC contraindicated AC not contraindicated AC not contraindicated Any indication‡
Mean follow-up, months (SD) 24.7 (16.1) NA NA 18.0 (10.0) 11.8 (5.8) 13 (NA)
CHADS2 score, mean (SD) 2.6 (1.2) 2.9 (1.3) NA 2.2 (NA) 2.6 (1.0) 2.8 (1.3)
CHA2DS2-VASc score, mean (SD) 4.2 (1.6) 4.3 (1.5) 4.3 (NA) NA 3.8 (1.2) 4.5 (1.6)
HAS-BLED score, mean (SD) 3.34 (1.17) 3.7 (1.1) NA NA NA 3.1 (1.2)
Device implanted (%):

  • Watchman

  • Amplatzer Cardiac Plug

  • Amplatzer Amulet

  • Others

  • Not specified

 63.0
34.7
0
2.3
0		 38.1
7.7
46.9
0.7
6.6		 2.6
50.4
41.0
6.0
0		 100
0
0
0
0		 100
0
0
0
0		 0
100 0
0
0
Procedural success (%) 92.5 89.0 99.1 91.0 95.1 97.3
Major procedural complications‡ (%) 3.5 5.5 4.9 NA 2.2 5.0
Periprocedural mortality (%) 0.25 0.95 0.76 NA NA 0.76
Discharge anti-thrombotic regimen (%):

  • Single APT

  • DAPT

  • OAC ± APT

 10.8
50.1
39.1		 NA NA 0
0
100		 0
0
100		 NA
Outcome measures‡ per 100 patient years:

  • Stroke, SE and mortality

  • Stroke, TIA or SE

  • All-cause or CV mortality

 NA
1.0
1.8		 9.8
5.0
6.2		 NA 3.0 ||
1.5 ||
1.0 ||		 5.2 ||
2.2 ||
2.6 ||		 NA
2.3
4.7

*LAA occlusion group only, †Includes absolute and relative contraindication for AC, resistant stroke, intolerance to OAC and lifestyle choice, ‡Includes absolute and relative contraindication for AC, resistant stroke, and drug interaction, ‡definition differs slightly between trials, ||estimates from CtE report. AC = anticoagulation; APT = antiplatelet therapy; CtE = Commissioning through Evaluation; CV = cardiovascular; DAPT = dual antiplatelet therapy; LAA occlusion = left atrial appendage occlusion; NA = not available; OAC = oral anticoagulation; RoW = rest of world; SE = systemic embolism; TIA = transient ischaemic attack.