Table 1.
Results of Hardy-Weinberg equilibrium (HWE) and Ewens-Watterson-Slatkin (EWS) tests at seven MHC loci in chimpanzees (pooled cohort) and humans (multiple populations)
| Chimpanzees (pooled cohort) | DPB1 | DQB1 | DQA1 | DRB1 | B | C | A |
|---|---|---|---|---|---|---|---|
| N | 44 | 48 | 29 | 46 | 51 | 51 | 50 |
| HWE p-value | 1 | 0.456 | 0.627 | 0.81 | 0.983 | 0.226 | 1 |
| EWS p-value (excess heterozygotes) | 0.079 | 0.873 | 0.100 | 0.031 | 0.645 | 0.811 | 0.069 |
| EWS p-value (excess homozygotes) | 0.491 | 0.970 | 0.707 | 0.473 | 0.907 | 0.945 | 0.572 |
| Humans (multiple populations) | DPB1 | DQB1 | DQA1 | DRB1 | B | C | A |
| k | 50 | 79 | 52 | 89 | 80 | 59 | 81 |
| (s.d) | 87.8 (45.2) | 100.6 (55.3) | 90.7 (45.5) | 105.5 (111.8) | 124 (134.6) | 127.9 (141.1) | 127.6 (133.6) |
| % HWE rejections (after correction) | 0 | 0 | 0 | 1.1 (0) | 0 | 0 | 0 |
| % EWS rejections (excess heterozygotes) | 0 | 16.46 (2.5) | 28.84 (0) | 30.34 (7.9) | 30 (0) | 33.9 (0) | 16.05 (3.7) |
| % EWS rejections (excess homozygotes) | 22 (2) | 1.27 (0) | 0 | 2.25 (0) | 5 (0) | 1.69 (0) | 7.41 (0) |
N: sample size (in number of individuals); k: number of populations; : mean sample size (in number of individuals); s.d.: standard deviation; Holm correction for multiple testing is given within brackets for the % of HWE and EWS tests. Significance tests were done without prior assumptions, thus two-tailed rejection at the 5% level either occurs below 0.025 (excess of heterozygotes) or above 0.975 (excess of homozygotes). The order of loci corresponds to their position on the chromosome from centromere (left) to telomere (right). The pooled cohort does not include Texascb (see Text)