Table 5.

Two-step epigenetic Mendelian randomization on cocaine and HIV severity (n = 1177)

CpG	Chr	Position	Nearest gene	Step 1: cocaine affecting methylation					Step 2: methylation affecting HIV severity
				Number of IV	Estimate	Standard error	95% CI	p value†	Number of IV	Estimate	Standard error	95% CI	p value†
cg03753191	13	43566902	EPSTI1	8	0.206	0.070	(0.069, 0.343)	3.27E−03	9	− 10.688	2.300	(− 15.197, − 6.180)	3.38E−06
cg06188083	10	91093005	IFIT3	8	0.269	0.109	(0.056, 0.482)	1.33E−02	4	− 6.756	2.602	(− 11.856, − 1.656)	9.42E−03
cg26312951	21	42797847	MX1	8	0.286	0.137	(0.018, 0.554)	3.68E−02	12	− 4.582	1.261	(− 7.053, − 2.111)	2.79E−04
cg22917487	3	39322103	CX3CR1	8	0.090	0.045	(0.001, 0.179)	4.83E−02	7	− 3.522	5.577	(− 14.453, 7.410)	5.28E−01
cg08122652	3	122281939	PARP9	8	0.259	0.141	(− 0.017, 0.536)	6.61E−02	8	− 4.517	1.558	(− 7.571, − 1.463)	3.75E−03
cg22930808	3	122281881	PARP9	8	0.245	0.164	(− 0.076, 0.567)	1.35E−01	10	− 5.245	1.135	(− 7.470, − 3.019)	3.85E−06
cg08818207	6	32820355	TAP1	8	0.092	0.071	(− 0.048, 0.231)	1.96E−01	2	− 10.287	5.519	(− 21.104, 0.530)	6.23E−02
cg03038262	11	315262	IFITM1	8	0.099	0.081	(− 0.059, 0.257)	2.20E−01	4	− 9.610	3.955	(− 17.361, − 1.859)	1.51E−02
cg22940798	6	32805554	TAP2	8	0.047	0.042	(− 0.035, 0.128)	2.62E−01	2	− 28.774	9.027	(− 46.466, − 11.082)	1.43E−03
cg06981309	3	146260954	PLSCR1	8	0.107	0.097	(− 0.083, 0.296)	2.69E−01	4	1.502	2.983	(− 4.344, 7.349)	6.15E−01
cg00096307	2	106761754	UXS1	8	0.036	0.033	(− 0.030, 0.101)	2.84E−01	2	3.455	11.853	(− 19.776, 26.685)	7.71E−01
cg07839457	16	57023022	NLRC5	8	0.109	0.158	(− 0.200, 0.418)	4.88E−01	7	− 2.961	1.552	(− 6.004, 0.081)	5.64E−02
cg26396492	20	19915762	RIN2	8	0.014	0.031	(− 0.047, 0.075)	6.50E−01	10	− 9.992	5.226	(− 20.234, 0.250)	5.59E−02
cg08623256	5	3858275		8	0.009	0.029	(− 0.048, 0.066)	7.58E−01	1	18.246	15.315	(− 11.772, 48.263)	2.34E−01
cg22385827	2	211036478	C2orf67	8	0.025	0.125	(− 0.219, 0.269)	8.41E−01	3	1.054	1.855	(− 2.582, 4.689)	5.70E−01

IV instrumental variable

^†p < 0.05 is bolded