Table 3.
Clusters of lower white matter FA in the LLD group compared with the NC group.
| Cluster index | White matter tractsa | Side | Cluster Size | MNI coordinates |
||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| 1 | Inferior fronto-occipital fasciculus | R | 5441 | 32 | 45 | 6 |
| Anterior thalamic radiation | R | |||||
| Uncinate fasciculus | R | |||||
| 2 | Anterior thalamic radiation | L | 536 | −17 | −61 | 46 |
| 3 | Inferior longitudinal fasciculus | L | 2131 | −49 | −27 | −15 |
| Superior longitudinal fasciculus (temporal part) | L | |||||
| Superior longitudinal fasciculus | L | |||||
| 4 | Inferior fronto-occipital fasciculus | L | 80 | −28 | −62 | 21 |
| Forceps major | ||||||
| 5 | Inferior fronto-occipital fasciculus | L | 34 | −23 | −86 | −2 |
| Inferior longitudinal fasciculus | L | |||||
| Forceps major | ||||||
a
White matter tracts as defined by the Johns Hopkins University White-Matter Tractography Atlas. All of the clusters were statistically significant (p < 0.05, FWE-corrected, controlling for sex, age, and antidepressant use). FA, fractional anisotropy; LLD, late-life depression; NC, non-depressed control.