Table 2.
Baseline values of the neuroimaging and clinical markers included in the LASSO Cox models.
| Marker | Overall sample, mean (SD) | MCI Progressors, mean (SD) | MCI Non-progressors, mean (SD) | t value | p value |
|---|---|---|---|---|---|
| Aβ GMM Probability | 0.26 (0.40)* | 0.68 (0.43) | 0.23 (0.37) | 4.96 | <0.001 |
| FDG PET uptake (SUVR) | 1.31 (0.12) | 1.26 (0.14) | 1.32 (0.12) | −1.91 | 0.07 |
| Default network connectivity | 0.25 (0.07) | 0.20 (0.07) | 0.25 (0.07) | −3.75 | < 0.001 |
| Salience network connectivity | 0.20 (0.05) | 0.17 (0.05) | 0.20 (0.05) | −3.16 | 0.004 |
| Control network connectivity | 0.27 (0.05) | 0.24 (0.05) | 0.27 (0.05) | −2.55 | 0.02 |
| Dorsal attention network connectivity | 0.23 (0.05) | 0.22 (0.06) | 0.23 (0.05) | −0.80 | 0.43 |
| Entorhinal Thickness (mm) | 3.35 (0.33) | 2.98 (0.23) | 3.39 (0.31) | −7.82 | < 0.001 |
| Parahippocampal thickness (mm) | 2.55 (0.31) | 2.42 (0.32) | 2.57 (0.30) | −2.13 | 0.04 |
| Average cortical thickness (mm) | 2.34 (0.09) | 2.31 (0.09) | 2.35 (0.09) | −1.80 | 0.08 |
| Hippocampal volume (mm3) | 3608 (4 3 3) | 3246 (3 9 0) | 3645 (4 2 0) | −4.64 | < 0.001 |
| Striatum volume (mm3) | 4104 (4 9 0) | 3987 (5 6 8) | 4116 (4 8 1) | −1.05 | 0.30 |
| Log transformed WMH (mm3) | 7.63 (0.91) | 7.99 (0.77) | 7.59 (0.91) | 2.35 | 0.03 |
| DTI FA | 0.511 (0.021) | 0.506 (0.018) | 0.512 (0.022) | −1.52 | 0.14 |
| FHS-CVD risk score (%) | 32.62 (18.03) | 38.23 (15.29) | 32.05 (18.21) | 1.81 | 0.08 |
| Memory factor score (z score) | −0.001 (0.76) | −0.43 (0.82) | 0.04 (0.74) | −2.64 | 0.01 |
| Executive function factor score (z score) | −0.02 (0.78) | −0.01 (0.84) | −0.02 (0.77) | 0.03 | 0.98 |
| Processing speed factor score (z score) | 0.01 (0.89) | −0.34 (1.07) | 0.05 (0.87) | −1.68 | 0.11 |
Baseline variables represent unstandardized (raw) values, with the exception of the factor scores, which represent z-score composites. GMM = Gaussian mixture modeling; FDG PET = 18F-fludeoxyglucose positron emission tomography; DTI FA = diffusion tensor imaging fractional anisotropy; FHS-CVD = Framingham Heart Study cardiovascular disease; MCI = mild cognitive impairment. SUVR = standard uptake value ratio, WMH = white matter hyperintensities. *For comparison purposes, the average Aβ distribution volume ratio across the whole sample is 1.16 (0.19).