Periodic Activation of the PA-Gal4cc Transcriptional Activators
(A–C) Transiently transfected HEK293T cells, in which PA-Gal4cc and 5x UAS-Ub-NLS-luc2-Ascl1 3′ UTR reporter had been introduced via lipofection, were repeatedly exposed to blue light pulses at 12- (A), 6- (B), or 3-h (C) intervals. The timing of blue light exposure is indicated by vertical blue lines. The first blue light illumination was initiated 24 h after the transfection. Experiments were repeated at least three times with similar results.