Table 2.
Laboratory results of severe COVID-19 patients with and without COPD.
| Normal range | COPD (n=28) | Non-COPD (n=308) | P value | |
|---|---|---|---|---|
| Median (IQR) | Median (IQR) | |||
| Blood routine | ||||
| Leukocyte count, ×109/L | 3.5–9.5 | 8.24 (5.23–13.67) | 5.72 (4.21–9.18) | 0.001 |
| Neutrophil count, ×109/L | 1.8–6.3 | 6.78 (3.92–10.96) | 3.54 (2.38–7.66) | 0.001 |
| Lymphocyte count, ×109/L | 1.1–3.2 | 0.46 (0.31–0.97) | 0.71 (0.51–1.27) | 0.012 |
| Monocyte count, ×109/L | 0.1–0.6 | 0.29 (0.21–0.47) | 0.41 (0.27–0.57) | 0.006 |
| Hemoglobin, g/L | 115–150 | 132 (117–146) | 113 (98–134) | 0.026 |
| Platelet count, ×109/L | 125–350 | 171 (125–224) | 178 (128–237) | 0.585 |
| Blood biochemistry | ||||
| ALT, U/L | ≤33 | 26 (15–45) | 23 (14–41) | 0.748 |
| AST, U/L | ≤32 | 36 (22–57) | 32 (19–55) | 0.637 |
| Albumin, g/L | 35–52 | 31 (24–45) | 33 (26–48) | 0.463 |
| UN, mmol/L | 3.1–8.8 | 7.1 (4.8–9.7) | 6.7 (4.0–9.1) | 0.379 |
| Cr, μmol/L | 45–104 | 76 (51–109) | 71 (42–101) | 0.281 |
| CK, U/L | ≤170 | 128 (64–282) | 113 (56–276) | 0.326 |
| LDH, U/L | 135–214 | 427 (342–619) | 459 (354–651) | 0.194 |
| NT-proBNP, pg/L | <285 | 729 (253–2421) | 422 (153–1028) | 0.001 |
| Blood coagulation | ||||
| PT, s | 9–13 | 12.4 (11.5–16.8) | 13.1 (12.2–17.9) | 0.871 |
| APTT, s | 25–31.3 | 32.4 (24.7–36.5) | 28.1 (21.4–30.8) | 0.415 |
| D-dimer, mg/L | 0–0.55 | 4.1 (1.3–16.4) | 1.9 (0.9–11.3) | 0.001 |
| Inflammatory markers | ||||
| hsCRP, mg/L | <1 | 79.6 (43.5–121.4) | 49.1 (32.8–93.2) | 0.001 |
| ESR, mm/H | 0–20 | 29.0 (14.0–55.6) | 33.2 (19.2–61.3) | 0.712 |
| Ferritin, μg/L | 15–150 | 1315 (564–2507) | 701 (278–1980) | 0.001 |
| IL-2R, U/mL | 223–710 | 962 (541–1237) | 576 (489–989) | 0.003 |
| IL-6, ng/L | <7 | 37.8 (10.1–112.8) | 32.1 (6.5–97.3) | 0.312 |
| IL-8, ng/L | <62 | 29.4 (12.1–60.5) | 34.1 (14.6–68.2) | 0.295 |
| IL-10, ng/L | <9.10 | 11.2 (4.1–15.8) | 13.5 (5.3–17.6) | 0.631 |
| TNF-α, ng/L | <8.1 | 14.5 (7.9–22.8) | 9.6 (5.1–13.1) | 0.001 |
| Bacterial infection marker | ||||
| PCT, ng/mL | 0.02–0.05 | 0.21 (0.10–1.15) | 0.09 (0.05–0.18) | 0.001 |
ALT – alanine aminotransferase; AST – aspartate aminotransferase; UN – urea nitrogen; Cr – creatinine; CK – creatine kinase; LDH – lactic dehydrogenase; PT – prothrombin time; APTT – activated partial thromboplastin time; hsCRP – high sensitive C-reactive protein; IL – interleukin; NT-proBNP – N-terminal pro-brain natriuretic peptide; TNF-α – tumor necrosis factor-α; PCT – procalcitonin; ESR – erythrocyte sedimentation rate. P<0.05 was defined as statistically significant.