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. 2020 Sep 4;26:e924453-1–e924453-10. doi: 10.12659/MSM.924453

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© Med Sci Monit, 2020

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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Effects of icariin on PI3K/AKT signal pathway in UA-induced cell injury. Min6 cells were treated with icariin, UA and/or glucose for the indicated times. Cells were divided into six groups: control, UA, UA+5 μM icariin, UA+10 μM icariin, UA+20 μM icariin. (A) P-PI3K and p-AKT levels measured by western blotting. (B) p-PI3K/PI3K and (C) p-AKT/AKT ratios. Levels of (D) PI3K and (E) AKT mRNAs determined by qRT-PCR. ** P<0.01 compared with the control group; ^# P<0.05, ^## P<0.01 compared with the UA group.