Table 1.
Patient characteristics
| Non-EoE control (N = 35) | HI EoE (N = 93) | Pa | |
|---|---|---|---|
| Demographics (n, %) | |||
| Age (mean ± SD) | 10.9 ± 4.2 | 9.7 ± 4.4 | 0.40 |
| Male | 18 (51.4) | 66 (71) | 0.06 |
| White | 31 (88.6) | 86 (92.5) | 0.49 |
| Hispanic | 6 (17.1) | 9 (9.7) | 0.35 |
| Comorbidities (n, %) | |||
| Asthma | 8 (22.9) | 40 (43) | 0.042 |
| Eczema | 12 (34.2) | 38 (40.9) | 0.55 |
| Allergic rhinitis | 16 (45.7) | 53 (57) | 0.32 |
| Food allergy | 4 (11.4) | 30 (32.3) | 0.024 |
| GERD | 6 (17.1) | 20 (21.5) | 0.81 |
| Visual findings (n, %) | |||
| Edema | 0 | 23 (24.7) | <0.001 |
| Exudate | 0 | 12 (12.9) | 0.036 |
| Furrows | 0 | 28 (30.1) | <0.001 |
| Rings | 0 | 19 (20.4) | 0.002 |
| Stricture | 0 | 0 | ND |
| Peak cells/hpf (mean ± SD) | |||
| Mast cell | 7.6 ± 5.7 | 16.7 ± 11.3 | <0.001 |
| Degranulated mast cell | 3.2 ± 3.6 | 6.7 ± 5.4 | <0.001 |
| Eosinophil | 1.4 ± 3.3 | 3.4 ± 3.9 | 0.001 |
| Histologic scoring (mean ± SD) | |||
| Epithelial score | 0.6 ± 1.6 | 2.2 ± 2.2 | <0.001 |
| Eosinophilia score | 0 ± 0 | 0.7 ± 0.7 | <0.001 |
a
Categorical variables compared with the Fisher exact test; continuous variables compared with unpaired 2-sample t-test.
EoE, eosinophilic esophagitis; GERD, gastroesophageal reflux disease; HI, histologically inactive; ND, not determined.