Figure 3.

Immunofluorescence analysis for ECM components in the SCBMs of wild type and Alport stria vascularis show no apparent differences. We previously showed that the SCBM thickening in Alport SCBMs was associated with accumulation of specific extracellular matrix molecules (Gratton et al., 2005; Meehan et al., 2016). This elevated expression is not observed in 3-week Alport mice compared to 3-week wild type mice. Data shown is representative of mid-modiolar sections from 3 animals per cohort. Lamα2 = laminin α2; Lama5 = laminin α5; Collagen IV = the α1 chain of collagen IV.