Table 1.
RNA-seq analysis of 3-week WT versus Alport stria vascularis.
| Cell-To-Cell Signaling and Interaction: Adhesion of tumor cell lines | |||
| Fold Change Alp vs WT | |||
| Gene Name | Protein | Average | Std Dev |
| Vcan | versican | 11.75 | 5.83 |
| Ctnna3 | catenin (cadherin associated protein), alpha 3 | 4.30 | 0.87 |
| Apoh | apolipoprotein H | 2.24 | 0.15 |
| Cdcp1 | CUB domain containing protein 1 | 1.69 | 0.10 |
| Itgal | integrin alpha L | 1.65 | 0.26 |
| Cell Death and Survival: Regeneration of axons | |||
| Fold Change Alp vs WT | |||
| Gene Name | Protein | Average | Std Dev |
| Rtn4r | reticulon 4 receptor | 1.87 | 0.44 |
| Cell Morphology: Formation of cellular protrusions | |||
| Fold Change Alp vs WT | |||
| Gene Name | Protein | Average | Std Dev |
| Tex14 | testis expressed gene 14 | 14.50 | 8.05 |
| Mapk8ip2 | mitogen-activated protein kinase 8 interacting protein 2 | 3.40 | 0.92 |
| Tnn | tenascin N | 3.33 | 0.58 |
| Gabrb3 | gamma-aminobutyric acid (GABA) A receptor, subunit β3 | 2.02 | 0.16 |
| Lrrc4 | leucine rich repeat containing 4 | 1.93 | 0.30 |
| Rtn4r | reticulon 4 receptor | 1.87 | 0.44 |
| Ctnna2 | catenin (cadherin associated protein), alpha 2 | −2.44 | .24 |
| Ksr2 | kinase suppressor of ras 2 | −4.35 | 5.29 |
| Cell Morphology: Sprouting | |||
| Fold Change Alp vs WT | |||
| Gene Name | Protein | Average | Std Dev |
| Tnn | tenascin N | 3.33 | 0.58 |
| Gabrb3 | gamma-aminobutyric acid (GABA) A receptor, subunit β3 | 2.02 | 0.16 |
| Lrrc4 | leucine rich repeat containing 4 | 1.93 | 0.30 |
| Ctnna2 | catenin (cadherin associated protein), alpha 2 | −2.44 | 0.24 |
| Cell Signaling: Small GTPase mediated signal transduction/Rho Protein signal transduction | |||
| Fold Change Alp vs WT | |||
| Gene Name | Protein | Average | Std Dev |
| Agtr1a | angiotensin II receptor, type 1a | 3.08 | 0.62 |
| Rtn4r | reticulon 4 receptor | 1.87 | 0.44 |
| Lpar2 | lysophosphatidic acid receptor 2 | 1.75 | 0.24 |
| Cellular Assembly and Organization: Depolymerization of filaments | |||
| Fold Change Alp vs WT | |||
| Gene Name | Protein | Average | Std Dev |
| Rp1 | retinitis pigmentosa 1 (human) | 2.53 | 0.50 |
| Mical2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | −1.54 | 0.07 |
| Cellular Assembly and Organization: Formation of cytoskeleton | |||
| Fold Change Alp vs WT | |||
| Gene Name | Protein | Average | Std Dev |
| Rp1 | retinitis pigmentosa 1 (human) | 2.53 | 0.50 |
| Ar | androgen receptor | 2.11 | 0.19 |
| Lpar2 | lysophosphatidic acid receptor 2 | 1.75 | 0.24 |
| Cellular Assembly and Organization: Formation and Polymerization of microtubules | |||
| Fold Change Alp vs WT | |||
| Gene Name | Protein | Average | Std Dev |
| Rp1 | retinitis pigmentosa 1 (human) | 2.53 | 0.50 |
| Cellular Assembly and Organization: Organization of cytoskeleton | |||
| Fold Change vs. WT | |||
| Gene Name | Protein | Average | Std Dev |
| Tex14 | testis expressed gene 14 | 14.50 | 8.05 |
| Fhl3 | four and a half LIM domains 3 | 3.62 | 0.87 |
| Mapk8ip2 | mitogen-activated protein kinase 8 interacting protein 2 | 3.40 | 0.92 |
| Tnn | tenascin N | 3.33 | 0.58 |
| Rp1 | retinitis pigmentosa 1 (human) | 2.53 | 0.50 |
| Ar | androgen receptor | 2.11 | 0.19 |
| Gabrb3 | gamma-aminobutyric acid (GABA) A receptor, subunit β3 | 2.02 | 0.16 |
| Lrrc4 | leucine rich repeat containing 4 | 1.93 | 0.30 |
| Rtn4r | reticulon 4 receptor | 1.87 | 0.44 |
| Mical2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | −1.54 | 0.07 |
| Aunip | aurora kinase A and ninein interacting protein | −1.92 | 0.59 |
| Ctnna2 | catenin (cadherin associated protein), alpha 2 | −2.44 | 0.24 |
| Ksr2 | kinase suppressor of ras 2 | −4.35 | 5.29 |