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a: HA applied tibia, two weeks treatment, stained with MT, ×25 magnification; b: HA applied tibia, two weeks treatment, stained with HE, ×25 magnification; c: NPY dose1 applied tibia, two weeks treatment, stained with HE, ×50 magnification; d: NPY1 receptor antagonist applied tibia, two weeks treatment, stained with Masson trichrome technique, ×25 magnification. The arrow shows the green stained new bone formation.
