Table 1.

Clinical and treatment characteristics of colchicine-tolerant and -intolerant groups.

	Colchicine tolerant N = 743	Colchicine intolerant N = 172	P
Female n (%)	452 (60.8%)	109 (62.6%)	0.770
Age, years	36.1 ± 11.3	38.59 ± 12.7	0.017
Smoking n (%) Alcohol usage n (%)	221 (29.7%) 65 (8.7%)	38 ( 26.7%) 13 (7.6%)	0.573 0.739
Education year	11.73 ± 4.12	11.76 ± 4.13	0.600
Age at FMF onset, years	13.71 ± 10.2	14.22 ± 11.65	0.790
FMF disease duration, years	22.43 ± 11.58	24.37 ± 13.21	0.054
Treatment duration, years	11.67 ± 7.89	12.01 ± 8.99	0.510
Number of mutations n (%) Mutation negative Single allelic mutation Biallelic mutation	52 (7%) 235 (41.4%) 332 (58.5%)	8 (5.6%) 60 (42.5%) 81 (57.4%)	0.950
Disease severity n (%) Mild Moderate Severe	383 (51.5%) 324 (43.6%) 36 (4.8%)	61 (35.3%) 84 (48.8%) 27 (15.6%)	0.001
Obesity	11.4%	10.6%	0.893
Comorbid disease* n (%) Hypertension Chronic kidney disease	179 (24.1%) 71( 9.6%) 7 (0.9%)	63 (36.6%) 27( 15.7%) 20 (11.6%)	0.0010.028<0.001
Concomitant medication n (%)	181 (24.4%)	52 (30.2%)	0.538

*Other than hypertension and chronic kidney disease, the frequency of other comorbidities was similar.