Table 2.
Intraoperative and postoperative parameters.
| Parameters | Group P (n = 69) | Group S (n = 90) | P value | Effect size | |
|---|---|---|---|---|---|
| Amount of rocuronium (mg) | 90.0 (70.0–107.5) | 120.0 (100.0–140.0) | <0.001* | 0.55 | |
| Amount of pyridostigmine (mg/kg) | 0.167 (0.153–0.189) | 0 (0–0) | - | - | |
| Amount of sugammadex (mg/kg) | 0 (0–0) | 2.08 (2.01–2.20) | - | - | |
| N2O used during two-lung ventilation | 39 (56.5) | 63 (70.0) | 0.079 | 0.14 | |
| N2O used during one-lung ventilation | 6 (8.7) | 8 (8.9) | 0.966 | 0.00 | |
| Anaesthesia time (min) | 245.0 (222.5–300.0) | 225.0 (220.0–310.0) | 0.535 | 0.05 | |
| Operation time (min) | 180.0 (149.5–236.5) | 186.5 (150.8–230.5) | 0.999 | 0.00 | |
| One-lung ventilation time (min) | 160 (130–202.5) | 163 (132.5–215) | 0.756 | 0.03 | |
| Extubation time (min) | 8.0 (5.0–15.0) | 7.0 (5.0–12.0) | 0.266 | 0.20 | |
| Fluid administered (mL) | 1050.0 (800.0–1337.5) | 950.0 (700.0–1475.0) | 0.769 | 0.02 | |
| Red blood cell transfusion | 8 (11.6%) | 6 (6.7%) | 0.398 | 0.09 | |
| Expired tidal volume during two-lung ventilation (mL) | 500 (500–600) | 500 (450–550) | 0.251 | 0.09 | |
| Respiratory rate during two-lung ventilation (cycles/min) | 12 (12–12) | 12 (12–13) | 0.067 | 0.15 | |
| Expired tidal volume during OLV (mL) | 339.6 ± 52.8 | 350.0 ± 60.8 | 0.223 | 0.20 | |
| Respiratory rate during OLV (cycles/min) | 15 (15–16) | 15 (15–16) | 0.086 | 0.14 | |
| Maximal pain score | 3.0 (3.0–5.0) | 3.0 (3.0–4.0) | 0.734 | 0.03 | |
| PONV | 8 (11.6%) | 4 (5.5%) | 0.235 | 0.11 | |
| pH | 30 min after OLV | 7.425 ± 0.052 | 7.446 ± 0.054 | <0.001* | 0.083 |
| Immediate post operation | 7.357 ± 0.039 | 7.381 ± 0.041 | |||
| POD0 night | 7.403 ± 0.053 | 7.408 ± 0.033 | |||
| POD1 morning | 7.407 ± 0.028 | 7.415 ± 0.027 | |||
| PO2 | 30 min after OLV | 203.6 ± 95.4 | 228.9 ± 104.8 | 0.044* | 0.026 |
| Immediate post operation | 149.6 ± 52.1 | 124.1 ± 39.3 | |||
| POD0 night | 183.6 ± 52.9 | 151 ± 49.9 | |||
| POD1 morning | 162 ± 47.4 | 142.3 ± 45.4 | |||
| PCO2 | 30 min after OLV | 41.6 ± 9.4 | 38.5 ± 6.4 | 0.003* | 0.057 |
| Immediate post operation | 44.9 ± 5.9 | 42.3 ± 4.6 | |||
| POD0 night | 39.6 ± 5.4 | 39.7 ± 4.4 | |||
| POD1 morning | 39.9 ± 5.7 | 38.6 ± 5.4 | |||
Data are presented as median (IQR), mean ± SD, or number (percentile). Group P: patients who received pyridostigmine as the reversal agent. Group S: patients who received sugammadex as the reversal agent. OLV: 1-lung ventilation; POD0: Postoperative day 0; POD1: postoperative day 1; POD2: postoperative day 2. Extubation time measured from the anaesthetics-off to the time of endotracheal tube extubation. The administered fluid volume present is the summed value of crystalloid and colloid, except the volume of blood products used. The maximal units of transfused red blood cells were 3. Maximal pain score is maximal NRS pain score measured from POD0 to POD2. PONV: number of patients with postoperative nausea and vomiting episode. The effect size was presented with a common effect size r for Mann–Whitney U test and Crémer’s V for chi-squared or Fisher’s exact tests, partial η2 for one-way ANOVA with one repeated factor. *