Table 2.
Lymphocytes subsets and immunoglobulin of STAT3 mutation patients
| P1 | P2 | P3 | P4 | P5 | P6 | P7 | P8 | P9 | P10 | P11 | P12 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lymphocytes subsets | ||||||||||||
| Total T cells (cells/μL) | 2418.05↑ (1325–2276) | 1640.43 (1325–2276) | 2210.10 (1480–2847) | 4180.60↑ (1775–3953) | 3722.60 (1794–4247) | 2748.03 (1775–3953) | 2198.60 (1325–2276) | 2484.20 (2187–6352) | 1704.50 (1424–2664) | 1524.7 (1775–3953) | 3343.50 (2187–6352) | 665.20↓ (1169–2071) |
| Total T cells (%) | 79.79↑ (57.10–73.43) | 72.59 (57.10–73.43) | 72.99 (59.50–75.56) | 71.41 (53.37–71.91) | 65.59 (53.88–72.87) | 64.26 (53.37–71.91) | 77.67↑ (57.10–73.43) | 60.47 (55.32–73.11) | 74.92 (60.05–74.08) | 59.09 (53.37–71.91) | 60.88 (55.32–73.11) | 79.77↑ (61.29–73.13) |
| CD4 T cells (cells/μL) | 935.32 (531–1110) | 859.30 (531–1110) | 1537.59 (767–1592) | 2784.37↑ (948–2477) | 2073.18 (902–2253) | 1900.82 (948–2477) | 1346.17↑ (531–1110) | 1403.91 (1125–3768) | 936.74 (686–1358) | 833.11 (948 –2477) | 1812.96 (1125–3768) | 347.24↓ (554–1109) |
| CD4 T cells (%) | 30.98 (24.00–38.72) | 37.96 (24.00–38.72) | 50.78↑ (28.49–41.07) | 47.56↑ (26.19–45.48) | 37.38 (24.08–42.52) | 45.86 (26.19–45.48) | 47.56↑ (24.00–38.72) | 34.17 (28.17–47.74) | 41.17 (26.17–40.76) | 32.29 (26.19–45.48) | 33.01 (28.17–47.74) | 39.03 (26.36–40.90) |
| CD8 T cells (cells/μL) | 1133.59 (480–1112) | 579.86 (480–1112) | 620.54 (553–1127) | 1291.87 (531–1521) | 1480.57 (580–1735) | 766.79 (531–1521) | 757.71 (480–1112) | 934.42 (686–2278) | 521.27 (518–1125) | 614.41 (531–1521) | 1299.38 (686–2278) | 265.24↓ (423–900) |
| CD8 T cells (%) | 37.26↑ (21.01–33.94) | 25.29 (21.01–33.94) | 20.49 (19.70–32.04) | 22.07 (16.29–29.88) | 25.38 (19.00–32.51) | 16.60 (16.29–29.88) | 26.77 (21.01–33.94) | 22.74 (15.88–31.48) | 22.91 (19.68–34.06) | 23.81 (16.29–29.88) | 23.66 (15.88–31.48) | 35.13↑ (20.99–33.73) |
| Total B cells (cells/μL) | 334.16 (216–536) | 228.69 (216–536) | 719.88 (303.52–777.25) | 1238.04 (537.11–1464.39) | 1500.17↑ (461–1456) | 1320.16 (537.11–1464.39) | 560.52↑ (216–536) | 957.21 (916–1832) | 366.17 (280–623) | 801.72 (537.11–1464.39) | 1732.5 (916–1832) | 116.07↓ (176.56–415.64) |
| Total B cells(%) | 11.23 (9.19–19.48) | 11.96 (9.19–19.48) | 23.78↑ (10.46–21.77) | 21.15 (13.93–30.49) | 26.67 (13.23–26.39) | 28.15 (13.93–30.49) | 19.80 (9.19–19.48) | 23.30 (17.20–29.71) | 16.09 (10.21–20.12) | 31.07 (13.93–30.49) | 31.55↑ (17.20–29.71) | 16.24 (7.73–16.84) |
| NK cells (cells/μL) | 245.275 (246–792) | 306.80 (246–792) | 64.19↓ (227–668) | 373.53 (241–978) | 386.41 (270–1053) | 329.45 (241–978) | 17.08↓ (246–792) | 597.21 (306–896) | 190.56↓ (258–727) | 208.92↓ (241–978) | 384.33 (306–896) | 32.05↓ (232–789) |
| NK cells(%) | 8.23 (10.01–26.98) | 14.31 (10.01–26.98) | 2.12↓ (7.83–20.99) | 6.38↓ (6.53–22.24) | 6.53↓ (7.21–20.90) | 6.03↓ (6.53–22.24) | 0.60↓ (10.01–26.98) | 14.53 (5.67–15.90) | 8.38↓ (9.00–22.24) | 8.1 (6.53–22.24) | 7.00 (5.67–15.90) | 2.85↓ (11.43–27.57) |
| CD4/CD8 | 0.84 (0.81–1.66) | 1.53 (0.81–1.66) | 2.48↑ (1.02–2.05) | 2.16 (1.05–2.53) | 1.52 (0.90–2.13) | 2.85 (1.05–2.53) | 1.78↑ (0.81–1.66) | 1.50 (0.93–2.52) | 1.80 (0.87–1.94) | 1.36 (1.05–2.53) | 1.4 (0.93–2.52) | 1.32 (0.85–1.76) |
| Immunoglobulin | ||||||||||||
| IgG (g/L) | 13.90 | 9.10 | 17.1↑ | 9.70 | 9.90 | 9.20 | 14.00 | 7.30 | 12.60 | 11.90 | 7.00 | 14.50 |
| IgA (g/L) | 1.16 | 1.15 | 2.76↑ | 0.63 | 0.56 | 0.18 | 0.32 | 0.16 | 1.27 | 0.71 | 0.18 | 1.30 |
| IgM (g/L) | 1.07 | 0.86 | 1.23 | 2.32 | 1.36 | 0.72 | 1.99 | 0.77 | 1.51 | 1.23 | 0.37 | 1.84 |
| IgE (KU/L) | 21,705.67↑↑↑ | 13,472.28↑↑↑ | 2660.19↑↑ | 6336.65↑↑ | 5021.83↑↑ | 3709.67↑↑ | 9015.51↑↑ | 67.2 | 17,310.4↑↑↑ | 1841.29↑↑ | 43.87 | 221.65↑ |
The number in round bracket presents the age specific reference values according to Reference Values for Peripheral Blood Lymphocyte Subsets of Healthy Children in China
The reference value of IgG, IgA, IgM and IgE is 6.09–12.85 g/L, 0.52–2.16 g/L, 0.67–2.01 g/L and < 100 KU/L, respectively