Fig. 6.

Oral administration of Ae can protect piglets against PEDV infection in vivo. (A) Macroscopic picture of intestine from a control piglet at 2 d.p.i. (B-C) Macroscopic pictures of intestine from Ae + PEDV and DMEM + PEDV-challenged piglets at 2 d.p.i. Thin-walled intestinal tracts were indicated by arrows. (D) H&E-stained jejunum tissue section of a control piglet at 2 d.p.i. (E-F) H&E-stained jejunum tissue section of Ae + PEDV and DMEM + PEDV-challenged piglets at 2 d.p.i. Blunt intestinal villus was indicated by arrows. (G) Immunohistochemically stained jejunum tissue section of a control piglet at 2 d.p.i. (H-I) Immunohistochemically stained jejunum tissue section of Ae + PEDV and DMEM + PEDV-challenged piglets at 2 d.p.i.. (J) The mortality of newborn piglets in each group was recorded from 1 to 2 d.p.i.. Data are represented as mean ± SD, n = 4.