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Rifapentine autoinduction profile. (A) The sigmoid relationship between rifapentine concentration and autoinduction is shown with the solid black line. Dashed lines represent the average concentration at a steady state of daily therapy with 300, 450, and 600 mg of rifapentine in a typical HIV-negative individual. (B) Rifapentine induction over time after daily administration of 600 mg. The black dashed line represents the time at which the induction process reaches a steady state.
