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Pharmacokinetic profiles of rifapentine following (A) a regimen of daily isoniazid-rifapentine for 1 month and (B) a regimen of once-weekly rifapentine-isoniazid for 3 months. Concentration–time profiles over 24 hours are shown for the typical adult by HIV status on (A) Day 21 of therapy, to reflect steady-state concentrations, and (B) after the first dose, as no accumulation occurs with weekly dosing.
