Table 4.
LMEM outcomes.
| # | Drug (Oxytocin, Placebo) | METH+ (Urine Toxicology) | Time (across 6 sessions) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ob | n | B(SE) | 95% CI | d | p | B(SE) | 95% CI | d | p | B(SE) | 95% CI | d | p | ||
| GQ | PB | 228 | 47 | 1.59(2.86) | [−4.02–7.20] | 0.08 | .581 | −1.26(1.99) | [−5.17–2.64] | −0.09 | .526 | 1.27(0.27) | [0.73–1.79] | .69 | <.001 |
| PW | 228 | 47 | 0.69(3.10) | [−5.39–6.77] | 0.03 | .825 | −0.354(1.86) | [−3.99–3.29] | −0.03 | .849 | 0.52(0.23) | [0.06–0.97] | 0.33 | .027 | |
| NR | 228 | 47 | −2.91(1.61) | [−6.06–0.25] | −0.26 | .078 | 3.48(1.37) | [0.79–6.17] | 0.37 | .013 | −0.46(0.25) | [−0.94–0.02] | −0.27 | .064 | |
| Pre-Session | Anxiety | 229 | 47 | −2.58(3.43) | [−9.31–4.15] | −0.11 | .456 | 6.19(2.59) | [1.11–11.28] | 0.35 | .018 | −1.22(0.39) | [−1.99 - −0.45] | −0.46 | .002 |
| Craving | 229 | 47 | −0.47(0.40) | [−1.26–0.32] | −0.17 | .249 | 0.56(0.32) | [−0.07–1.19] | 0.26 | .082 | −0.11(0.05) | [−0.21–0.004] | −0.32 | .043 | |
| Urge | 229 | 47 | −0.14(0.39) | [−0.91–0.63] | −0.05 | .719 | 0.57(0.31) | [−0.04–1.18] | 0.27 | .072 | −0.18(0.05) | [−0.28 - −0.09] | −0.53 | <.001 | |
| Pre- to Post-Session Change | Anxiety | 230 | 47 | −0.30(1.74) | [−3.71–3.10] | −0.03 | .863 | −1.82(1.65) | [−5.06–1.42] | −0.16 | .276 | 0.26(0.42) | [−0.56–1.09] | 0.09 | .533 |
| Craving | 229 | 47 | 0.24(0.21) | [−0.17–0.65] | 0.17 | .256 | −0.11(0.21) | [−0.52–0.31] | −0.08 | .618 | 0.05(0.06) | [−0.07–0.16] | 0.12 | .437 | |
| Urge | 229 | 47 | −0.15(0.23) | [−0.59–0.30] | −0.10 | .527 | −0.10(0.22) | [−0.52–0.32] | −0.07 | .639 | 0.11(0.06) | [−0.01–0.23] | 0.27 | .065 | |
| Psycho-physiology | HR | 181 | 46 | −9.14(3.49) | [−15.98 - −2.30] | −0.39 | .013 | 9.14(2.75) | [3.76–14.52] | 0.49 | .001 | 0.27(0.41) | [−0.53–1.07] | 0.10 | .510 |
| RSA | 181 | 46 | 0.66(0.43) | [−0.18–1.50] | 0.23 | .132 | −1.27(0.28) | [−1.81 - −0.72] | −0.67 | <.001 | −0.01(0.04) | [−0.08–0.06] | −0.04 | .774 | |
| RMSSD | 180 | 46 | 10.09(5.07) | [−0.16–20.03] | 0.29 | .052 | −13.60(4.08) | [−21.58 - −5.61] | −0.49 | .001 | −0.24(0.64) | [−1.50–1.02] | −0.06 | .710 | |
Fixed effect estimates (B), standard error (SE), 95% Confidence Interval (CI), effect sizes (d), and p-values for secondary outcomes, looking at main effect of Drug (oxytocin versus placebo), METH use, and Time (across six sessions).
GQ = Group Questionnaire, HR = heart rate, LMEM = linear mixed effects model, METH = methamphetamine, NR = Negative Relationship, Ob = Observations, PB=Positive Bonding, PW=Positive Working, RMSSD = root mean square of the successive differences, RSA = respiratory sinus arrhythmia.