TABLE 4.
Enriched Biological Pathways functional clusters (EBPfc) affected by MatSep.
| Category | Term | Count | % | p-value | FE | FDR |
| Neonates | ||||||
| GOTERM_CC_DIRECT | GO:0005615∼extracellular space | 34 | 17 | 0.00000 | 2.49 | 0.00 |
| GOTERM_BP_DIRECT | GO:0045087∼innate immune response | 18 | 9 | 0.00000 | 7.20 | 0.00 |
| GOTERM_BP_DIRECT | GO:0006954∼inflammatory response | 13 | 6.5 | 0.00005 | 4.34 | 0.07 |
| GOTERM_BP_DIRECT | GO:0043065∼positive regulation of apoptotic process | 12 | 6 | 0.00091 | 3.35 | 1.45 |
| KEGG_PATHWAY | rno04060:Cytokine-cytokine receptor interaction | 10 | 5 | 0.00065 | 4.08 | 0.78 |
| GOTERM_BP_DIRECT | GO:0006955∼immune response | 10 | 5 | 0.00089 | 4.00 | 1.43 |
| GOTERM_BP_DIRECT | GO:0006915∼apoptotic process | 10 | 5 | 0.01347 | 2.64 | 19.59 |
| GOTERM_BP_DIRECT | GO:0043547∼positive regulation of GTPase activity | 10 | 5 | 0.01722 | 2.53 | 24.35 |
| GOTERM_CC_DIRECT | GO:0031012∼extracellular matrix | 9 | 12.2 | 0.00000 | 9.92 | 0.00 |
| GOTERM_BP_DIRECT | GO:0008284∼positive regulation of cell proliferation | 7 | 9.46 | 0.00940 | 3.79 | 12.84 |
| KEGG_PATHWAY | rno04640:Hematopoietic cell lineage | 7 | 3.5 | 0.00026 | 7.68 | 0.31 |
| KEGG_PATHWAY | rno04015:Rap1 signaling pathway | 6 | 8.11 | 0.00064 | 7.97 | 0.74 |
| GOTERM_MF_DIRECT | GO:0005125∼cytokine activity | 6 | 3 | 0.01663 | 4.02 | 20.32 |
| GOTERM_BP_DIRECT | GO:0043123∼positive reg I-kappaB kinase/NF-kappaB | 6 | 3 | 0.02272 | 3.71 | 30.87 |
| GOTERM_BP_DIRECT | GO:0050727∼regulation of inflammatory response | 5 | 2.5 | 0.00309 | 8.22 | 4.85 |
| GOTERM_BP_DIRECT | GO:0030199∼collagen fibril organization | 4 | 5.41 | 0.00040 | 27.27 | 0.58 |
| KEGG_PATHWAY | rno04261:Adrenergic signaling | 4 | 5.41 | 0.01227 | 7.87 | 13.29 |
| GOTERM_BP_DIRECT | GO:0070555∼response to interleukin-1 | 4 | 2 | 0.01056 | 8.72 | 15.69 |
| GOTERM_BP_DIRECT | GO:0002250∼adaptive immune response | 4 | 2 | 0.03103 | 5.81 | 39.74 |
| GOTERM_MF_DIRECT | GO:0005518∼collagen binding | 3 | 4.05 | 0.01396 | 16.34 | 15.22 |
| KEGG_PATHWAY | rno04370:VEGF signaling pathway | 3 | 4.05 | 0.01760 | 14.05 | 18.53 |
| GOTERM_BP_DIRECT | GO:0010759∼pos regul of macrophage chemotaxis | 3 | 1.5 | 0.00548 | 26.15 | 8.45 |
| Adult | ||||||
| GOTERM_BP_DIRECT | GO:0070374∼positive regulation of ERK1 and ERK2 | 6 | 4.17 | 0.01355 | 4.23 | 19.01 |
| GOTERM_MF_DIRECT | GO:0020037∼heme binding | 5 | 3.47 | 0.02451 | 4.51 | 27.99 |
| GOTERM_MF_DIRECT | GO:0005506∼iron ion binding | 5 | 3.47 | 0.04604 | 3.68 | 46.40 |
| KEGG_PATHWAY | rno04062:Chemokine signaling pathway | 5 | 3.47 | 0.04885 | 3.34 | 51.85 |
| KEGG_PATHWAY | rno04060:Cytokine-cytokine receptor interaction | 4 | 14.3 | 0.00236 | 12.75 | 2.11 |
| GOTERM_BP_DIRECT | GO:0090263∼pos regulation of canonical Wnt path | 4 | 2.78 | 0.01583 | 7.51 | 21.87 |
| GOTERM_BP_DIRECT | GO:0042102∼pos regulation of T cell proliferation | 3 | 10.7 | 0.00390 | 30.63 | 4.84 |
| KEGG_PATHWAY | rno05323:Rheumatoid arthritis | 3 | 10.7 | 0.00567 | 23.42 | 5.01 |
| GOTERM_BP_DIRECT | GO:0007623∼circadian rhythm | 3 | 10.7 | 0.01247 | 16.80 | 14.71 |
| GOTERM_BP_DIRECT | GO:0019221∼cytokine-mediated signaling pathway | 3 | 10.7 | 0.01487 | 15.31 | 17.31 |
| GOTERM_BP_DIRECT | GO:0046329∼negative regulation of JNK cascade | 3 | 2.08 | 0.01571 | 15.44 | 21.72 |
| KEGG_PATHWAY | rno04330:Notch signaling pathway | 3 | 2.08 | 0.04698 | 7.61 | 50.68 |
| GOTERM_BP_DIRECT | GO:0031295∼T cell co-stimulation | 2 | 7.14 | 0.02834 | 66.63 | 30.56 |
Data was analyzed using DAVID Functional Annotation Bioinformatics Microarray Analysis. FE = Fisher’s exact test, FDR = Force discovery rate.