Table 3:

Age-dependent regulation of ACE2, TMPRSS2 and apoptosis in human lung

Human age:		0–30 days (Newborn)	1–12 months (Infant)	1–17 years (Child)	18–45 years (Adult)	45–64 years (Late Adult)	65–74 years (Elderly)	75+ (Advanced Age)
ACE2 mRNA Lung Epithelial		Low	Moderate/High	Moderate	Moderate	Not available	Not available	Not available
ACE2 mRNA Lung Endothelial		None	None	None	Low	Not available	Not available	Not available
ACE2 in Lung Cells	All (DAPI+)	Not available	High	Low, variable	Moderate, variable	Moderate, variable	High, variable	High, variable
	AQP3+	Not available	Not available	Moderate, variable	Moderate, variable	Moderate, variable	Moderate, variable	Moderate, variable
	PDPN+	Not available	Not available	Low, variable	Moderate, variable	Moderate, variable	High, variable	High, variable
TMPRSS2 mRNA Lung Epithelial		None	Moderate	Low	Low	Not available	Not available	Not available
TMPRSS2 mRNA Lung Endothelial		None	None	None	Low	Not available	Not available	Not available
Apoptotic Priming		Not available	Not available	Not available	Not available	Not available	Not available	Not available
BCL-2 Family Gene Expression	Pore-Forming	Moderate	Moderate	Moderate	Moderate	Not available	Not available	Not available
	Pro-Apoptotic	Moderate	Moderate	Moderate	Low	Not available	Not available	Not available
	Pro-Survival	Moderate	Moderate	Moderate	High	Not available	Not available	Not available