4. Factors affecting overall diagnostic yield of EBUS-GS in PPLs (N=109).

Variables	Total (N)	Diagnostic yield by EBUS-GS [n (%)]	Univariate analysis		Multivariate analysis
Variables	Total (N)	Diagnostic yield by EBUS-GS [n (%)]	OR (95% CI)	P	OR (95% CI)	P
EBUS-GS, endobronchial ultrasonography with guide sheath; PPL, peripheral pulmonary lesion; CT, computed tomography; Within type, the probe was placed in a bronchus that ran inside the lesion; Adjacent type, the probe was placed in a bronchus that ran alongside the lesion; Without type, the probe was placed in a bronchus that far from the lesion or the probe could not access the lesion for exploration; OR, odds ratio; 95% CI, 95% confidence interval.
Sex
Female	49	37 (75.5)	1
Male	60	44 (77.3)	1.121 (0.471−2.668)	0.796
Age (year)
>60	50	35 (70.0)	1
≤60	59	46 (78.0)	1.516 (0.640−3.595)	0.344
Lesion size on CT (mm)
≤20	44	27 (61.4)	1
>20	65	54 (83.1)	3.091 (1.272−7.521)	0.013	2.758 (1.077−7.062)	0.034
Lobe location on CT
Lower lobe	32	21 (65.6)	1
Upper lobe	66	51 (77.3)	1.781 (0.703−4.511)	0.224
Middle lobe	11	9 (81.8)	2.357 (0.432−12.864)	0.322
Lung field on CT
Intermediate band	60	43 (71.7)	1
Lateral band	49	38 (77.6)	1.366 (0.569−3.276)	0.485
Bronchus sign on CT
Absent	27	16 (59.3)	1
Present	82	65 (79.3)	2.629 (1.032−6.696)	0.043	1.679 (0.582−4.842)	0.337
Probe position on EBUS
Adjacent or without type	46	27 (58.7)	1
Within type	63	54 (85.7)	4.222 (1.686−10.572)	0.002	3.174 (1.151−8.757)	0.026
Sample methods
Single use	19	11 (57.9)	1
Combined use	90	67 (74.4)	2.545 (0.902−7.183)	0.078	1.350 (0.410−4.445)	0.622