12. Adjuvant chemoradiotherapy stratification treatment recommendations for stage II−III rectal cancer.

Risk stratification for recurrence of stage II−III rectal cancer	Treatments	Recommended level
CRM, circumferential resection margin; TME, total mesorectal excision; MRF, mesorectal fascia.
Meeting any of the following criteria	Postoperative concurrent chemoradiotherapy	Recommended
CRM ≤1 mm
pT4b
pN2 with poor TME quality/mesorectum defect
Pathology stage II/III but the quality of TME operation could not be evaluated
The nerve infiltrates near MRF
Pathology stage II/III but unable to assess CRM status
Meeting all the following criteria	Postoperative concurrent chemoradiotherapy	Suggested
CRM is 1−2 mm
Circumferential obstruction tumor
Meeting all the following criteria	Postoperative concurrent chemoradiotherapy	Not suggested
TME quality is good/mesorectum smooth and complete
pT1−3 or pT4a above the peritoneal reflection
pN0−1
CRM >2 mm